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Sebetralstat Tablets (Ekterly)

The U.S. Food and Drug Administration has approved sebetralstat, the first oral, on-demand treatment for acute attacks of hereditary angioedema. Sebetralstat is a selective competitive, reversible plasma kallikrein inhibitor. It is distributed by KalVista Pharmaceuticals Inc as Ekterly.

Contemporary Cardiovascular Disease Deaths in Asian Americans

An analysis of a Centers for Disease Control and Prevention database has shown the cardiovascular disease mortality rate is higher in Asian Americans than in non-Asian Americans and that this excess mortality is particularly prevalent in Filipino Americans.

Fidaxomicin Is More Clinically Effective than Vancomycin for C. difficile Infection

There is a lack of real-world data on using fidaxomicin for Clostridioides difficile infection (CDI). A retrospective, single-center study found that treatment of CDI with fidaxomicin leads to reduced clinical failure compared to oral vancomycin.

SGLT2 Inhibitor Plus Aldosterone Antagonist for HFpEF: Safe? Efficacious?

A prospective, open-label, blinded outcome crossover trial of dapagliflozin plus spironolactone vs. dapagliflozin alone in patients with heart failure with preserved or mildly reduced left ventricular ejection fraction resulted in a greater reduction in natriuretic peptides, which was accompanied by a greater decline in kidney function and a rise in serum potassium.

ApoB vs. Lp(a): Which Is More Important for CAD Risk?

In U.K. Biobank participants without known atherosclerotic cardiovascular disease or diabetes or taking lipid-lowering therapy, the risk of developing coronary artery disease is best determined by apolipoprotein B particle number, but elevated lipoprotein(a) adds significant risk, so both should be considered.

The Proton Pump Inhibitor Use and Hypertension Link in Menopausal Women

In a large study, long-term use of proton pump inhibitors in menopausal women was associated with an increased risk of developing hypertension.

Acute STEMI or Something Else?

Interpret the electrocardiogram (ECG) in the figure without the benefit of any clinical information. Is this ECG indicative of an acute anterior ST-elevation myocardial infarction?

Taletrectinib Capsules (Ibtrozi)

The U.S. Food and Drug Administration has approved a potent, selective, next-generation ROS Proto-Oncogene 1 (ROS1) receptor tyrosine kinase inhibitor, taletrectinib, for the treatment of ROS1-positive non-small cell lung cancer.

Do Gowns Help Prevent Transmission of Respiratory Viruses?

The authors examined various studies to look at the effectiveness of different kinds of gowns and materials in preventing viral infections. The results were mixed, with most studies demonstrating no good evidence that gowning helps in this regard.

Examining Fecal Microbiota Transplant for Primary C. difficile Infection

In a randomized controlled trial conducted in Norway, fecal microbiota transplantation (FMT) was noninferior to vancomycin for the treatment of primary Clostridioides difficile infection, with 66.7% of patients in the FMT group achieving clinical cure without recurrence compared to 61.2% in the vancomycin group over 60 days of follow-up.