Browse Internal Medicine Alert Articles by Topic

Long-Term Peripheral Nerve Function in People with Well-Controlled Type 2 Diabetes

The authors conducted a prospective observational study comparing the effect of early diagnosed, well-controlled type 2 diabetes on peripheral nerve function. Overall, they found similar rates of decline in nerve function in people with well-controlled diabetes compared to age- and sex-matched individuals with normal glucose tolerance. Given the similar decline in nerve function, the authors concluded that the course of diabetic sensorimotor neuropathy is influenced primarily by nerve function at the time of diagnosis and age-related physiological decline.

Semaglutide May Reduce Dementia Risk

In a large nationwide population-based study, semaglutide significantly reduced Alzheimer’s disease-related dementia risk compared to insulin, metformin, and older glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes.

Can Vitamin D Supplementation Slow Cellular Aging?

In a large randomized, double-blind, placebo-controlled trial, vitamin D3 supplementation modestly but significantly slowed the rate of leukocyte telomere shortening over four years.

Pediatric Tachycardia?

The electrocardiogram in the figure is from a previously healthy 15-year-old boy who reports palpitations and dizziness over the past two weeks. How would you interpret this tachycardia?

Avutometinib Capsules and Defactinib Tablets (Avmapki Fakzynja CO-PACK)

The U.S. Food and Drug Administration has granted accelerated approval for a combination of two kinase inhibitors, avutometinib and defactinib, for the treatment of KRAS-mutated recurrent low-grade serous ovarian cancer who have received prior systemic therapy, including a platinum-based regimen.

Why Does Colonization Become Active C. difficile?

These authors performed a nested case-control study to identify risk factors for the progression from Clostridioides difficile colonization to active infection in hospitalized persons.

Post-Traumatic Headaches: Common and Complicated

The brain’s ability to modulate pain influences the development and persistence of post-traumatic headache (PTH). Functional magnetic resonance imaging (fMRI) studies in people with PTH show higher pain-induced brain activation in specific regions, such as the postcentral gyrus, superior temporal gyrus, and ventral striatum, as compared to healthy controls. Over 16 weeks of observation, progressive normalization in pain-induced brain activation was seen in the PTH group with headache improvement, with persistently elevated activation in the non-improvement PTH group.

Patients Hospitalized for Non-Severe COVID-19: No Benefit of CAP Antibiotics

A large population-based, retrospective, cohort study found there was no benefit for antibiotics targeting community-acquired pneumonia in patients hospitalized with non-severe COVID-19. These results provide evidence against antibiotic use in this population.

Weight Loss Without Bone Loss: Mediterranean Diet and Exercise in Older Women

This systematic review found that, among older women undergoing intentional weight loss, bone density is better preserved with a calorie-restricted Mediterranean diet combined with physical activity, compared to a standard Mediterranean diet alone.

Telisotuzumab Vedotin-tlly (Emrelis)

The U.S. Food and Drug Administration has granted accelerated approval of telisotuzumab vedotin-tilly, a first-in-class c-mesenchymal-epithelial transition factor-directed antibody and a microtubule inhibitor conjugate for the treatment of locally advanced or metastatic, non-squamous non-small cell lung cancer.