Neurology
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Intravenous Immunoglobulin for Treatment of Autoimmune Epilepsies
Patients with LGI1 and CASPR2 IgG-associated autoimmune epilepsy were identified and randomized to treatment with intravenous immunoglobulin (IVIG) vs. placebo. The authors hypothesized that IVIG would show superiority over placebo, with a primary endpoint of 50% or greater seizure reduction.
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Rituximab for the Treatment of MOG and AQP4 Antibody Diseases
Based on an observational prospective study of 16 patients with anti-myelin oligodendrocyte protein (MOG) disease and 29 anti-aquaporin-4 disease, the authors report lesser efficacy of rituximab in anti-MOG patients, characterized by higher occurrence of relapses in the anti-MOG group, even while the biological effect of rituximab on memory B-cell suppression was sustained.
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Neurofilament Light Correlates With Postoperative Delirium Severity
Measurement of postoperative plasma neurofilament light protein (NfL) in plasma appears to have a dose-dependent correlation with delirium severity, independent of inflammation. This observation provides evidence of neuronal injury from delirium.
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Icosapent Ethyl Capsules (Vascepa)
Icosapent is the first drug approved to reduce the risk of cardiovascular events in patients with established cardiovascular disease and hypertriglyceridemia on maximally tolerated statin therapy.
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CNS Agents Emerge as Frontrunners in FDA-Approved Treatments for Low Libido in Women
Low libido is the most common sexual complaint, affecting up to 38.7% of women, with up to 12.3% also reporting significant distress associated with this condition. Debate continues about how female desire disorders are characterized, diagnosed, and treated.
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The Risk of Endocarditis With Bacteremia
Interrogation of the Danish National Patient Registry revealed bacteremia due to Enterococcus faecalis was most likely to be associated with infective endocarditis; thus, echocardiography is warranted in these patients.
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Fever of Unknown Origin Due to Cat Scratch Disease
Disseminated cat scratch disease may present as a fever of unknown origin.
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Longer Antibiotic Courses for Pneumonia Do Not Improve Outcomes, Do Cause More Adverse Effects
Excess antibiotic therapy did not improve mortality or morbidity outcomes, although each additional antibiotic day was associated with 3% increased odds of antibiotic-associated adverse drug events.
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Can One Be Certain About the Rhythm Diagnosis?
The 12-lead ECG and long lead II rhythm strip in the figure was obtained from a patient who was hemodynamically stable. What is the rhythm in the figure? Why can one be virtually certain what the rhythm diagnosis is before attempting a vagal maneuver or using medication?
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Ubrogepant Tablets (Ubrelvy)
Ubrogepant is indicated for the acute treatment of migraine with or without aura in adults.