Neurology
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Prognosis in Small Fiber Neuropathy
Small fiber neuropathy is a common disorder that causes chronic pain, but rarely progresses to disability or more severe neurological disorders. Management of the pain continues to be the major treatment challenge.
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Colonization With Clostridioides difficile Frequently Leads to a Misdiagnosis of Healthcare-Associated Infection
A prospective cohort study from a single institution revealed 27% of patients diagnosed with healthcare-associated Clostridioides difficile infection were colonized with the same isolate on admission.
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Does Exercise Decrease Incident Depression in a High-Risk Population?
The authors of this large-scale, observational study found that three or more hours weekly of physical activity was associated with a decreased incidence of depression, even in patients with a high genetic risk of depression.
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Therapeutic Hypothermia in Coma After Cardiac Arrest With Nonshockable Rhythm
Therapeutic hypothermia is beneficial and increases the probability of brain recovery in patients with coma due to cardiac arrest with a nonshockable heart rhythm.
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Immune Cell Infiltration Drives Cerebral Edema in Glioblastoma
Accumulating evidence suggests that immune dysregulation by glioblastoma cells induces tumor-associated edema and that disruption of this tumor-immune interaction may represent a novel strategy to reduce cerebral edema in glioblastoma.
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Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis
In this prospective, population-based study, mean lifetime heritability of amyotrophic lateral sclerosis was 52% in the entire cohort and 37% in patients devoid of any known pathogenic mutations. The highest heritability was seen in mother-daughter parings in both groups.
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Spontaneous Anterior Interosseous Nerve Syndrome
Anterior interosseous nerve syndrome is part of the median neuropathy spectrum and often has been attributed to compression near the elbow. Modern magnetic resonance neurography and ultrasound studies have ruled-out compression in most cases.
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Diagnostic Criteria for Small Fiber Neuropathy
Multiple clinical tools have emerged to assess small fiber nerve dysfunction, but validated diagnostic criteria are needed to optimize diagnostic sensitivity, support clinical management, and facilitate patient selection for clinical trials.
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Lemborexant Tablets (Dayvigo)
Lemborexant should be prescribed to treat adults with insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
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Stable Coronary Disease and Atrial Fibrillation Patients Best Treated With Rivaroxaban Alone
Monotherapy with rivaroxaban was noninferior to combination therapy for the primary efficacy endpoint of composite of stroke, systemic embolism, myocardial infarction, unstable angina, or death from any cause.