Neurology
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Cognitive Symptoms in Genetic Forms of Parkinson’s Disease May Help in Distinguishing the Various Types
This paper illustrates that, of the confirmed genetic forms of Parkinson’s disease, there are common cognitive and psychiatric features, thus adding to our knowledge of the clinical phenotype of these genetic forms.
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Zilucoplan for Myasthenia Gravis
Zilucoplan, a macrocyclic peptide that binds complement component C5, showed promise as an effective agent for treatment of generalized myasthenia gravis in a Phase II trial.
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Special Report from the 2020 International Stroke Conference, Los Angeles
These reviews of studies presented at the 2020 International Stroke Conference were written by Neurology Alert's editor after personal attendance at the presentations, followed by review of the simultaneous publications in Stroke. All comments and opinions are solely those of the editor.
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Osilodrostat Tablets (Isturisa)
Osilodrostat should be prescribed to adult patients with Cushing's disease for whom pituitary surgery is not an option or has not been curative.
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Cannabis in the Treatment of Headache and Migraine
The authors of this observational study found nearly a 50% reduction in self-reported headache and migraine severity following use of inhaled medicinal cannabis.
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Warfarin or DOACs for Atrial Fibrillation in Chronic Kidney Disease?
A large outpatient observational study of patients with atrial fibrillation and chronic kidney disease who were anticoagulated revealed that, compared to warfarin, direct oral anticoagulants exhibited less all-cause mortality and major bleeding with at least equivalent efficacy at preventing stroke.
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Anatomic vs. Functional Testing in Older Coronary Artery Disease Patients
An analysis of the PROMISE trial by age showed cardiovascular death or myocardial infarction was predicted by a positive stress test in patients with symptoms suggesting myocardial ischemia who were > age 65 years.
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Pharmacotherapy Considerations for COVID-19
A summary of selected pharmacotherapy options proposed to treat COVID-19.
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This ECG Was in Your ‘Pile to be Read’
Imagine the ECG in the figure was one of many tracings you received to read from a group of patients seen by other providers in your clinic. Unfortunately, no clinical information about this patient was available. How would one interpret this tracing? Considering no clinical information regarding what happened to the patient was available, what is the next step?
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Rimegepant Orally Disintegrating Tablet (Nurtec ODT)
Rimegepant should be prescribed to treat acute migraine with or without aura in adults.