Browse Neurology Alert Articles by Topic

Diagnosing POLG-related Diseases

Mutations of the polymerase-gamma subunit in mitochondrial DNA is a common cause of adult mitochondrial syndromes, such as myopathies, encephalopathies, epilepsy, and ataxias.

Prevalence of Rest Tremor in Essential Tremor

Rest tremor is seen in patients with more advanced essential tremor, yet its prevalence varies significantly between patient groups.

Cerebrospinal Fluid Biomarkers of Neuronal Injury in Mild AD

Cerebrospinal fluid visinin-like protein 1 is a useful marker, along with CSF tau and phospho-tau measurements, to predict brain atrophy and neurodegeneration in patients who carry a clinical diagnosis of Alzheimer’s disease.

Serum and CSF Biomarkers of Brain Injury After Sports-related Concussion

ABSTRACT & COMMENTARY: So far none of the currently measured biomarkers has sufficient sensitivity or specificity to be clinically useful.

Neurologic Disease and Criminal Behavior – A Medicolegal Conundrum

Patients with frontotemporal dementia, primary progressive aphasia, and Huntington’s disease exhibited antisocial and/or criminal behavior.

Intracranial Clot Extraction Results in Better Outcomes than Intravenous Thrombolysis Alone

This article will discuss three studies that have been recently published in the New England Journal of Medicine — MR CLEAN, ESCAPE, and EXTEND — regarding intracranial clot extraction for acute ischemic stroke

Restless Legs Syndrome and Post-polio Syndrome

Restless legs syndrome is prevalent in patients with post-polio syndrome and is associated with decreased quality of life and fatigue.

Update in Treating Neuropathic Pain

In an exhaustive review of the literature with a meta-analysis, the following medications were found to be most efficacious in the treatment of neuropathic pain: gabapentin, pregabalin, serotonin-noradrenaline reuptake inhibitors including duloxetine or venlafaxine, and tricyclic antidepressants.

‘The Butterfly Effect’ Explains Weather Triggering of Migraine

For about 13% of patients with migraine, a change in weather may be a trigger for some headaches; however, there is no specific perturbation in meteorological measures that is likely to predict a headache.

Autologous Hematopoietic Stem Cell Transplant for Relapsing-Remitting MS

Interim analysis at 3 years post-treatment of a study of high-dose immunosuppression and autologous hematopoietic stem cell transplant for relapsing remitting-multiple sclerosis demonstrates sustained disease control but also shows potential risks associated with this treatment.