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Idarucizumab: A Promising New Drug that Reverses the Anticoagulant Effects of Dabigatran

A recent study found that idarucizumab rapidly reverses the effects of dabigatran and is likely to have important clinical benefits for patients with intracerebral hemorrhage and other disease processes in which reversal of anticoagulation is important.

Nerve Biopsy for Asymptomatic Vasculitic Neuropathy

Nerve biopsy is a safe and highly sensitive definitive diagnostic test for systemic vasculitis, even without symptoms of peripheral neuropathy, when electrodiagnostic tests indicate an axonal neuropathy.

Migraine and Cognitive Dysfunction

During an attack of migraine without aura, patients may experience transient cognitive impairment, with predominant involvement of verbal processing speed, learning, and memory, due to reversible cortical dysfunction.

RYR1-related Myopathies

Ryanodine receptor gene mutations are among the most common genetic disorders found in a variety of congenital myopathies, both mild and severe.

A Modern Epidemiologic View of Status Epilepticus in the United States

In this retrospective review of mortality and hospitalization related to status epilepticus from 1999 to 2010, the authors found that overall mortality remained relatively stable, whereas the rate of related hospitalizations significantly increased, particularly in patients who were intubated and in whom status epilepticus was not the primary diagnosis.

Scrub Typhus and the Brain

Scrub typhus infections involve the nervous system in a majority of cases and should be suspected in patients who live in, or are returning from, endemic regions with a compatible clinical syndrome.

GAD Antibody Syndromes: When to Dig Deeper

This retrospective case series identifies the clinical and immunologic features of GAD antibody-positive patients who should be screened for an underlying cancer.

Convexal Subarachnoid Hemorrhage and Amyloid Angiopathy

Cerebral amyloid angiopathy is emerging as a major cause of spontaneous intracerebral hemorrhage in the elderly. The authors of this study undertook a careful review of all of the patients in their database over a 9-year period who had spontaneous convexal subarachnoid hemorrhage, and they performed a careful longitudinal analysis of clinical and neuroimaging data.

Consequences of Intracerebral Hemorrhage in Young Adults

Intracerebral hemorrhage accounts for 10-20% of all strokes in North America and Europe, with an overall incidence of 25 cases per 100,000 population annually. In this study, the authors evaluated the long-term survival and recovery of 268 1-month survivors ages 16-49 years to assess the prognosis of intracerebral hemorrhage in the younger group.

Can Dietary Intervention Delay the Onset of Alzheimer’s Disease?

In a prospective study of an elderly population, moderate adherence to the MIND diet was associated with a 53% reduction in the development of Alzheimer’s disease.