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A Possible New Treatment for HTLV-1-associated Myelopathy

Mogamulizumab reduces central nervous system inflammation and improves spasticity in patients with HTLV-1-associated myelopathy.

Parsonage-Turner Syndrome: Where’s the Lesion?

SYNOPSIS: This careful analysis of MRI imaging of the brachial plexus in patients with well-defined Parsonage-Turner Syndrome showed that the lesions are in peripheral branches of the brachial plexus and not in the roots or cords.

Lessons Learned From a Failed Anti-amyloid Trial for Alzheimer’s Disease

Despite the disappointing results in EXPEDITION 3, modifications of clinical trials for Alzheimer’s disease (AD) should be undertaken and trials targeting preclinical or early AD should continue with anti-amyloid agents.

Postpartum Headache May Be a Symptom of a Serious Problem

Consultation for acute postpartum headache resulted in the diagnosis of a secondary cause of headache in almost three out of four women, with almost half of the secondary headaches due to a hypertensive disorder of pregnancy or to cerebrovascular disease.

Coprescription of Triptans and SSRI-type Medications and the Serotonin Syndrome

A recent study provided reassurance that the use of triptan antimigraine medications with selective serotonin reuptake inhibitor and selective norepinephrine reuptake inhibitor antidepressants is safe.

Autoimmune Encephalitis: Not Rare and Increasing

Detection of autoimmune encephalitis is increasing over time. According to the results from this population-based study, its prevalence and incidence are comparable to infectious encephalitis.

Salivary microRNA as Biomarker to Predict Prolonged Concussion Symptoms

In a prospective cohort study of pediatric patients, aged 7 to 21 years, diagnosed with concussion, salivary microRNAs were found to be a potential biomarker for predicting prolonged concussion symptoms.

Treatment for Autoimmune Small-fiber Neuropathy

The cause of most cases of small-fiber neuropathy is uncertain, but many patients have accompanying autoimmune biomarkers. In a carefully selected group of such patients, intravenous immunoglobulin treatment appears to provide benefit.

Proceedings From the International Stroke Conference, Los Angeles, February 2018

Message from the editor: The following reviews of studies presented at the 2018 International Stroke Conference were written after my personal attendance at the presentations, followed by review of the simultaneous publications in the journals Stroke, The New England Journal of Medicine, JAMA Neurology, and the Journal of the American Medical Association.

Serum Tau as a Reliable Biomarker of Outcome After Cardiac Arrest

Currently, there are no reliable and readily available biomarkers to assist in determining prognosis for neurological recovery after cardiac arrest, but serum tau measurements hold promise for the future.