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Longitudinal tau PET as an Outcome Measure for Clinical Trials

tau PET imaging shows progression of brain Alzheimer’s pathology over time and correlates with cognitive impairment better than amyloid PET. In future clinical trials, tau PET can serve as a biomarker for Alzheimer’s disease progression.

What Are the Early Predictors for Post-traumatic Epilepsy After Injury?

Following traumatic brain injury, early (first five days after injury) epileptiform abnormalities on EEG were seen more commonly in patients with subsequent post-traumatic epilepsy (PTE), compared to controls, and were found to be a significant and independent predictor of PTE. The presence of subdural hemorrhage was the only other independent predictor of PTE.

Intracranial Pressure Changes in Mild Traumatic Brain Injury

After an exhaustive review of the animal and human studies literature regarding mild traumatic brain injury (mTBI), Haider et al. did not reach consistent conclusions regarding evidence for intracranial pressure elevation in human patients who sustain an mTBI.

Prediction of Persistent Post-concussion Symptoms After Mild Traumatic Brain Injury

Persistent post-concussion syndrome may last for more than six months, and risk factors include female sex, neck pain, headache, and post-concussive symptoms at two weeks after the injury.

Postoperative Atrial Fibrillation After Coronary Artery Bypass Graft

The data from this study do not indicate that new-onset postoperative atrial fibrillation should be regarded as having the same risks as primary nonvalvular atrial fibrillation in terms of long-term thromboembolic risk, and that anticoagulation in this group may not be necessary unless the atrial fibrillation is persistent.

Opioids Not Better for Chronic Back Pain

Chronic use of opioids for management of back pain is controversial and hotly debated. This randomized trial showed no benefit of opioids over multimodality non-opioid treatments, consistent with many other observational studies.

Rapid Screening for Future Risk of Parkinson’s Disease Dementia

The Montreal Parkinson Risk of Dementia Scale provides a simple eight-item screening tool with high predictive value for developing Parkinson’s disease dementia.

Sleep Habits and the Development of Dementia

The relationship between quality of sleep and the development of dementia is controversial and not yet clearly elucidated nor understood.

Differences Between Type 1 and Type 2 Diabetic Neuropathy

Microstructural nerve damage in distal symmetric diabetic neuropathy differs between subjects with type 1 diabetes (T1D) and type 2 diabetes (T2D). The predominant nerve lesions in T1D correlated with hyperglycemia and nerve conduction impairment, while the predominant lesions in T2D correlated with dyslipidemia.

Phenytoin as a Second-line Treatment for Status Epilepticus: What’s the Evidence?

In this systematic review, the evidence supporting the use of intravenous phenytoin for convulsive status epilepticus was analyzed critically and did not demonstrate strong evidence to support its use as a preferred second-line agent.