Neurology Alert
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Pain in Anti-MAG Neuropathy
Most patients with anti-MAG neuropathy complain of painful paresthesias or dysesthesias, but unlike diabetic neuropathy, these symptoms are not severe and do not affect quality of life as much as motor weakness.
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Myasthenia Gravis, MuSK, and Pregnancy
Myasthenia gravis increases both maternal and fetal complications and mortality during pregnancy, but the MuSK-antibody variant appears less morbid, based on this small retrospective series of 17 patients.
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Functional Imaging Studies in Parkinson’s Disease
A meta-analysis of 142 studies demonstrated that functional imaging studies in Parkinson’s disease using tracers for aromatic acid decarboxylase showed smaller defects compared to those using tracers targeting dopamine transport and VMAT2. Symptom severity correlated linearly with dopamine neuron loss as determined by these imaging studies.
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Targeting Hypersensitive Corticostriatal Terminals to Treat Restless Legs Syndrome
SYNOPSIS: Based on this innovative study using optogenetic microdialysis, the mechanisms underlying restless legs syndrome include dopamine-mediated hypersensitivity of corticostriatal neurons to glutamate release.
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Neuroimmunology and Movement Disorders: When Should We Test for Autoantibodies?
Autoantibody-associated neurological disorders can mimic neurodegenerative and other movement disorders, but are likely under-diagnosed, resulting in missed treatment opportunities. This review is a “must read” for all neurologists.
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Thrombectomy Is Effective Up to 24 Hours After Stroke – the DAWN Trial
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Isolated Amyloid Myopathy
Isolated amyloid myopathy is a rare disorder that can be distinguished from systemic amyloidosis with myopathy by clinical, biochemical, and muscle biopsy histologic criteria.
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TBI in Prodromal Parkinson’s Disease
This population-based study using Medicare data demonstrated that in the five years prior to diagnosis of Parkinson’s disease (PD), when compared with age-matched controls, those who were diagnosed with PD had a higher incidence of traumatic brain injury (TBI). The TBI was rated as mild and concussive and was most often related to falls.
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Blockade of CGRP for Migraine Prevention: Promising, but Not a Cure
Blockade of calcitonin gene-related peptide in patients with chronic or episodic migraine results in the prevention of about two headache days a month compared to placebo.
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The Incidence of Dementia May Be Declining
In community-dwelling people from Bronx County, New York, there was a sharp decrease in dementia incidence in those born after mid-1929, which could not be readily explained by changes in the prevalence of cardiovascular diseases, higher education, or increased racial/ethnic diversity.