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The diagnosis of amyotrophic lateral sclerosis (ALS) at an early stage can be difficult. It is desirable to have an accurate diagnostic test due to the prognosis of the illness, as well as the potential ability to treat patients earlier.
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Fifty-one consecutive hepatitis c patients with neuropathy were evaluated to determine whether, and by what mechanism, cryoglobulinemia was associated with peripheral neuropathy.
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Benbadis and associates reviewed the medication history of patients with EEG-confirmed idiopathic generalized epilepsy.
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In this elegant study, Seif and colleagues asked a simple question: does DBS alter urodynamic parameters in patients with Parkinson's disease?
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Relying on careful monitoring to reduce the risk of toxicity, Ritchie and colleagues carried out a 36-week phase II test of the efficacy of clioquinol in reducing plasma beta-amyloid levels and slowing cognitive decline in patients with moderately severe Alzheimer's disease.
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In contrast to arterial thrombo-embolic ischemic stroke, cerebral venous sinus thrombosis (CVST) is unique in its clinical presentation and treatment algorithm. As reported by Ferro and associates on behalf of the multicenter international ISCVT study, venous stroke, typically treated with heparin, has a good outcome in the vast majority of cases.
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Non-pharmacologic treatment options for patients of epilepsy include resective epilepsy surgery, vagal nerve stimulation, the ketogenic diet, and experimental protocols. Of these, epilepsy surgery offers the greatest chance of curing the patients epilepsy. To achieve this degree of success, it is critical to localize the epileptogenic zone as accurately as possible. Pataraia et al estimates that MEG provides additional localizing information in 40% of their patients.
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Men and women with restless legs syndrome (RLS), aged 18-79 years, were included in this randomized, 12-week, double-blind, placebo-controlled study conducted at 43 centers in 10 European countries, designed to assess the efficacy of ropinirole, a dopamine agonist, in the treatment of RLS. Ropinirole significantly improved IRLSSG score at 12 weeks compared to placebo, with benefit evident even at week 1.
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This report described the results of a double-blind, placebo-controlled study of flupirtine maleate (FLU), a triaminopyridine compound in patients with Creutzfeldt-Jakob disease (CJD). The patients with flupirtine showed significantly less deterioration in the dementia tests than the patients treated with placebo.
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The prospects for therapy in Huntingtons disease are rapidly improving. Another potential treatment is to use striatal neural grafts.
