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Presepsis Pathways: Can We Predict Mortality After Sepsis Hospitalization?

Using a latent profile analysis in observational cohort studies of patients hospitalized for sepsis, investigators identified subtypes of patients based on inpatient healthcare facility use in the year prior to sepsis hospitalization and correlated to 90-day mortality.

Ventilator-Associated Pneumonia and Hospital-Acquired Pneumonia: Prevention and Treatment

Ventilator-assisted pneumonia and hospital-acquired pneumonia pose significant risks to hospitalized patients and increase the cost of care. It is essential to institute measures to reduce the risk of these pneumonias and to recognize and treat them early when they occur. Treatment is a balance of ensuring adequate antimicrobial coverage in those who already are seriously ill while not unduly exposing them to the risks of medication side effects and higher rates of resistant organisms that come with the use of broad-spectrum antibiotics.

Brexanolone Injection (Zulresso)

Brexanolone is indicated for the treatment of postpartum depression.

Update on Treatments for Vulvovaginal Atrophy

As with many clinical conditions, the spectrum of genitourinary syndrome of menopause requires the clinician to consider the effect on the patient’s quality of life. Although situational lubricants and regular moisturizers effectively pacify many symptoms, local estrogen is a safe, effective, and affordable way to treat the vulvovaginal changes of menopause.

Imagine: Multidrug-Resistant Acute Gonococcal Infection

What would happen if clinicians lost ceftriaxone as an effective therapy for gonococcal infection?

Probiotics Do Not Prevent C. difficile Infection in Hospitalized Patients

A retrospective cohort study from a single California hospital revealed the administration of probiotics to patients receiving antibiotics did not reduce the incidence of healthcare facility-onset Clostridioides difficile infection.

Does Physical Activity Lower the Risk of Parkinson’s Disease?

A systematic review and meta-analysis incorporating more than 500,000 subjects revealed that moderate to vigorous physical activity is associated with a significant reduction in development of Parkinson’s disease; this relationship is most pronounced in men.

Is There AV Block?

The long lead II rhythm strip in the figure was recorded at the standard 25 mm/second speed. This tracing was obtained from a middle-aged woman who presented to an outpatient clinic with noncardiac chest pain. How would one interpret this rhythm? Are there signs of AV block? Is it apparent if there is a cardiac problem?

Esketamine Nasal Spray (Spravato) CIII

Esketamine, in conjunction with an oral antidepressant, is indicated for the amelioration of treatment-resistant depression in adults.

Witness Observations in Diagnosing Transient Loss of Consciousness

Investigators found that adding witness-reported observations to patient demographics and patient-reported symptoms improved the diagnostic accuracy between epilepsy, syncope, and psychogenic nonepileptic seizures.