Browse Internal Medicine Articles by Topic

Cholecystokinin as a Biomarker Linking Metabolic Function to Alzheimer’s Disease

In a study cohort from the Alzheimer’s Disease Neuroimaging Initiative, cerebrospinal fluid levels of cholecystokinin were associated with better outcomes that may reflect compensatory protection as Alzheimer’s disease pathology progresses. However, because of significant study limitations, these findings need to be validated in additional studies.

Lacosamide for Painful Small Fiber Neuropathy Due to Voltage-Gated Sodium Channel Mutations

The results of this randomized trial showed significant neuropathic pain score reduction with the use of lacosamide in patients with Nav1.7 mutations.

Measurement of Brain Vital Signs in Concussed Athletes

These investigators prospectively studied auditory event-related potentials (ERPs) in junior competitive male ice hockey players and identified a pattern of ERPs that distinguishes acutely concussed from non-concussed players, establishing this noninvasive, easy-to-administer test as a biomarker to assist trainers, coaches, and clinicians with making the diagnosis of concussion.

PrabotulinumtoxinA-xvfs Injection (Jeuveau)

PrabotulinumtoxinA-xvfs is indicated for temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adults.

Ripples From Original WHI Study Results Continue: Is This Appropriate?

Recommendations for menopausal hormone therapy were widely publicized and adopted following the original publication of the results of the Women’s Health Initiative, affecting both initiation and continuation of estrogen therapy through at least 2013.

Dual Antiplatelet Therapy With Cilostazol for Secondary Stroke Prevention (LB3)

In a recent trial, patients treated with dual antiplatelet therapy combining cilostazol with either aspirin or clopidogrel were at a lower risk of ischemic stroke recurrence and at a similar risk of significant bleeding compared to patients treated with aspirin or clopidogrel alone.

IV to Oral Conversion of Antibiotic Therapy for Bacteremia Due to Enterobacteriaceae

Oral step-down antibiotic therapy (IV to oral conversion) is safe and effective in patients with bloodstream infection due to Enterobacteriaceae.

Rethinking the Prophylactic Use of Proton Pump Inhibitors in the ICU

The authors of this multicenter, blinded, randomized trial found that among critically ill adults at risk for gastrointestinal (GI) bleeding, fewer patients in the pantoprazole group exhibited clinically important GI bleeding compared to placebo, although mortality at 90 days was similar in both groups.

An Update to the Management of Atrial Fibrillation

This focused update to the 2014 guidelines for the management of atrial fibrillation (AF) includes revisions to anticoagulation recommendations and the role of catheter ablation of AF in patients with heart failure.

Corticosteroid Administration in Sepsis May Be Associated With Lower 28-Day Mortality

In this systematic review and meta-analysis of randomized, controlled trials comparing administration of corticosteroids with placebo or standard supportive care in sepsis, corticosteroids were associated with reduced 28-day mortality.