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Corticosteroid Administration in Sepsis May Be Associated With Lower 28-Day Mortality

In this systematic review and meta-analysis of randomized, controlled trials comparing administration of corticosteroids with placebo or standard supportive care in sepsis, corticosteroids were associated with reduced 28-day mortality.

When to Screen for and Treat Asymptomatic Bacteriuria

New guideline recommendations indicate that the only unequivocal indications for screening and treatment of asymptomatic bacteriuria are pregnancy and undergoing endoscopic urologic procedures associated with mucosal injury.

Viruses, Food Allergies, and Childhood Wheezing

Infants with severe bronchiolitis sometimes develop subsequent recurrent wheeze and asthma. Among infants hospitalized with bronchiolitis, the risk of developing asthma is greatest in those with rhinovirus C infection, especially if they also are sensitized with IgE against foods.

Oral Antibiotics Are Noninferior to Intravenous for Bone and Joint Infections

In a randomized, controlled trial of adult patients with bone or joint infections, researchers found oral antibiotic therapy was noninferior to intravenous therapy based on treatment failure at one year.

The Right Ventricle During Heart Failure With Preserved Left Ventricular Ejection Fraction

A retrospective longitudinal study of heart failure with reduced left ventricular ejection fraction shows that right ventricular function deteriorates more rapidly than left ventricular function and is associated with increased mortality.

New Insights Into Young Acute Myocardial Infarction Patients

A retrospective contemporary review of STEMI patients younger than 35 years of age shows that these patients are predominantly overweight men who smoke (some abuse drugs and present with dyslipidemia).

Transcatheter Mitral Valve Replacement

A large registry study of transcatheter mitral valve replacement showed excellent results in failed bioprostheses but less overall success in failed mitral valve repairs with rings and conditions associated with mitral annular calcium.

Early Cardiac Catheterization After Resuscitation From Cardiac Arrest

In this first-ever randomized trial about comatose patients without ST-segment elevation who have been resuscitated from cardiac arrest, immediate coronary angiography showed no benefit over delayed coronary angiography in terms of 90-day survival.

Team-Based Approach Associated With Better Outcomes in Cardiogenic Shock

Implementation of a standardized, team-based approach to cardiogenic shock resulted in improved 30-day survival compared to historical controls.

Saline vs. Balanced Crystalloids in Critically Ill Adults

Balanced crystalloids appear to reduce in-hospital mortality in critically ill patients with sepsis or without traumatic brain injury and may reduce in-hospital mortality in the entire cohort of critically ill patients.