Infectious Disease
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Cirrhosis and Infections
Infections in patients with cirrhosis are frequent and potentially lethal, with pneumonia associated with the highest risk for mortality.
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Influenza Vaccination Reduces the Risk of Major Cardiovascular Events
A meta-analysis of six randomized, controlled trials revealed receipt of influenza vaccination reduced the risk of major cardiovascular events compared to the unvaccinated, with 56 patients needing vaccination to prevent one event. Higher-risk patients had 45% reduced risk.
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Travelers Need Pre-Trip Hepatitis A Vaccination
Hepatitis A continues to be a problem for international travelers in much of the world. More widespread use of hepatitis A vaccine could be warranted.
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Monkeypox in the United States
The first 17 patients in the United States affected by the current monkeypox outbreak are described. Of note is the absence of reported fever in 10, and the frequent presence of lymphadenopathy, as well as of genital and perianal lesions.
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Monkeypox in Europe and North America: What to Expect, What to Do
Data on outcomes of monkeypox cases managed in Europe and North America are limited but provide some clues on epidemiology, clinical manifestations, treatment, and outcome.
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An Epic Battle: SARS-CoV-2 vs. the Human Immune System
Penny Moore, PhD, an HIV researcher for about two decades, has redeployed much of her research to measure humoral immune response to SARS-CoV-2 infection and vaccination.
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WHO Cooperative Treaty for Next Pandemic Begins in Controversy
The World Health Organization is continuing discussions of an international treaty or framework for global cooperation during the next pandemic, but the effort may struggle to gain traction in a divided, highly politicized environment currently holding sway in the United States.
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Monkeypox Countermeasures Include Vaccines, PEP, and Antiviral Treatment
Although monkeypox cases are expected to increase as a result of the national call to clinicians to identify cases, the United States has no surfeit of medical countermeasures. These include two vaccines, a vaccinia immune globulin intravenous product, an antiviral drug, and large testing capacity.
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Special Report: Monkeypox Spread to 29 Non-Endemic Nations Unprecedented
The near-simultaneous emergence of monkeypox in the United States, Europe, and other regions where it rarely is seen has raised questions whether the virus could become endemic beyond West and Central Africa, where outbreaks are more common.
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Mavacamten Capsules (Camzyos)
Mavacamten can be prescribed to adults with symptomatic New York Heart Association class II-III obstructive hypertrophic cardiomyopathy to improve functional capacity and symptoms.