Infectious Disease
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Immunomodulatory Treatment of Disseminated Coccidioidomycosis
A previously healthy 4-year-old boy with no prior serious illnesses was diagnosed with disseminated coccidioidomycosis with prominent skin and bone involvement. Despite treatment with liposomal amphotericin B, antifungal azoles, and surgical debridement, the patient developed progressive disease. Treatment with interferon-gamma slowed disease progression, and later treatment with interleukin-4 and interleukin-13 blockade induced remission of his infection.
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Rotavirus Vaccine Is Safe and Effective
Routine rotavirus vaccination of infants, when implemented broadly, is safe and is associated with reductions in diarrhea-related hospitalizations, mortality, and morbidity (such as malnutrition) in children.
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Outcomes with Daptomycin Plus a β-Lactam Compared to Daptomycin Alone for MRSA Bacteremia
In a retrospective cohort study, investigators found the addition of a β-lactam antibiotic to daptomycin led to less clinical failure (60-day all-cause mortality and/or 60-day recurrence) in patients with methicillin-resistant Staphylococcus aureus bacteremia.
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COVID-19 in Early Infancy
An evaluation of 18 infants with COVID-19 in the first three months of their lives found that the illness generally was not severe despite the presence of very high viral loads.
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COVID-19: Lessons from Spring Break
A high rate of COVID-19 occurred as the result of an outbreak in spring breakers. Rapid recognition and intervention, as well as the youth and good health of those infected, was effective in limiting the adverse consequences.
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Updated Guidelines for HPV Vaccine
Recommendations call for providing vaccine to boys and girls starting at age 9 years.
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Pandemic Necessity Is the Mother of Invention
Hospital clinicians are using creative strategies and producing their own equipment to meet the outsized demands of treating patients during the novel coronavirus pandemic, the Society for Healthcare Epidemiology of America reports.
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Pandemic Coronavirus May Kill the Handshake
The COVID-19 pandemic may be the death knell of the handshake, although its deep anthropological roots may resurface after the viral storm is over.
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Effects of COVID-19 on the Brain
Healthcare workers and patients who have contracted SARS-CoV-2, particularly if they were hospitalized, could be at risk of neurological deficits in the short term and as well as later cognitive problems.