Infectious Disease
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IDSA Sepsis Committee and SEP-1 Quality Measures
The IDSA Sepsis Committee proposes that The Centers for Medicare & Medicaid Services’ Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) should be applied only to septic shock, not sepsis without shock.
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Contact Isolation Is Not Better than Standard Precautions for Decreasing Acquisition of ESBL-Producing Enterobacterales
In a multicenter, cluster-randomized crossover trial, researchers compared standard precautions vs. contact isolation for preventing acquisition of ESBL-producing Enterobacterales (ESBL-E) in non-intensive care unit settings. Contact isolation did not decrease the number of hospital-acquired ESBL-E cases, which questions the value of the practice.
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Monotherapy of Pseudomonas aeruginosa Bacteremia — Which β-Lactam Antibiotic Is Best?
No significant difference in the mortality of patients with Pseudomonas aeruginosa bacteremia was seen regardless of treatment with a carbapenem, ceftazidime, or piperacillin-tazobactam. However, the emergence of resistance occurred significantly more frequently in those treated with a carbapenem — largely related to imipenem use.
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Macrolides During Pregnancy — Behind the Headlines
Despite published concerns, there is no good evidence that macrolide use during pregnancy causes birth defects.
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Remdesivir and COVID-19
Remdesivir is safe and moderately effective in the treatment of patients with COVID-19.
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CDC Updates Guidance on COVID-19 Transmission in Dental Settings
The Centers for Disease Control and Prevention has updated infection control guidelines for COVID-19 in dental settings, including new information on facility and equipment considerations and using test-based strategies to inform patient care.
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Public Health Nurses Share Views on Vaccine Education
Debates on how to best respond to outbreaks of vaccine-preventable infections continue. Opinions about mandating vaccines, including if, how, and when, vary widely.
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Sharply Divided (and Evolving) Views on Vaccine Refusers
As the world anxiously awaits a vaccine for COVID-19, an ethical debate rages over whether people should be allowed to refuse it.
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CDC’s COVID-19 Guidelines on Going Out and Gathering Have Cautions and Caveats
Trying to strike a balance epidemiologically, and perhaps politically, the Centers for Disease Control and Prevention has issued guidelines for people wanting to leave home and attend gatherings as COVID-19 cases generally have plateaued nationally.