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The developing brain of a child may be particularly susceptible to injury from mild traumatic brain injury, such as a concussion. Recommending a longer period of strict rest after a concussion does not provide additional benefit when compared to consensus guidelines for care after a concussion in children and adolescents. However, in retired former NFL players, exposure to tackle football prior to age 12 is associated with executive dysfunction, memory impairment, and lower estimated verbal IQ later in life.
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The tap test has variable results as a tool to assess patients with a presumed diagnosis of normal pressure hydrocephalus.
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In a restrospective review, rituximab appeared beneficial for patients with medication-resistant myasthenia gravis.
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New recommendations for HPV vaccine; guidelines for treatment of essential tremor; updates on smoking cessation drugs; and FDA actions.
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Forty-nine clinical centers and 18 positron emission tomography (PET) centers in the United States and Canada participated in a randomized, blinded-adjudication clinical treatment trial of 195 patients with symptomatic atherosclerotic internal carotid artery occlusion (AICAO) who also had hemodynamic cerebral ischemia identified by ipsilateral increased oxygen extraction fraction measured by PET.
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Teriflunomide, an orally administered inhibitor of dihydro-orotate dehydrogenase, was found to be superior to placebo in reducing relapses in a 2-year, Phase 3 clinical trial in patients with multiple sclerosis.
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Menstrually related migraine is difficult to treat and options are limited. Hormonal manipulation is controversial and unproven.
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Surgical removal of brain metastases remains an important part of palliative therapy for metastatic cancer.
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Extracorporeal membrane oxygenation is associated with a high mortality and a high incidence of neurological complications including stroke, subarachnoid hemorrhage, and brain death.
