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Opioid-induced Nausea and Vomiting
Opioids are highly effective when administered for appropriate indications. Unfortunately, opioid-induced nausea and/or vomiting (OINV) can limit opioid effectiveness. In the immediate postoperative period, OINV can stress wound integrity and prolong hospital stay. In the outpatient setting, some patients are faced with the dilemma of accepting lesser levels of pain control in exchange for less OINV as they consider whether they should decrease their opioid dosing schedule.
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FDA Actions
In this section: The FDA unveils new adverse events dashboard tool, announces intent to hasten generic drug approvals, greenlights a generic drug to treat multiple sclerosis, greenlights biosimilar to treat multiple types of cancers, gives go ahead to leukemia treatment, and approves updated herpes zoster vaccine.
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Possible Adverse Cardiovascular Events Slow Osteoporosis Drug Approval Process
Romosozumab appears to outperform alendronate for fracture prevention in women with osteoporosis, but an increase in cardiovascular adverse events has derailed FDA approval.
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Comparing Two Important Hormone Therapy Treatments
New data from the Women’s Health Initiative may be reassuring for women on postmenopausal hormone therapy. The data show no higher mortality rate with hormone use after long-term follow-up.
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What Is the Appropriate Length of Opioid Prescriptions After Routine Surgeries?
Postsurgical opioid prescriptions often lead to extra pills stored in unsecured locations in homes. This represents a potential source for non-medical opioid use and associated morbidity and mortality for patients and their families.
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Aberrant Conduction or Ventricular Bigeminy?
How would you interpret the tracing? Are these multifocal (multiform) premature ventricular contractions?
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Clinical Briefs
In this section: managing diabetes; elective surgery; and nephrolithiasis patients.
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Tisagenlecleucel Suspension (Kymriah)
Kymriah is indicated for the treatment of patients up to 25 years of age with B-cell precursor acute lymphoblastic leukemia that is refractory or in second or later relapse.
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What Is the Ideal Target for Blood Pressure Control?
Researchers organized a study to address quality-of-life outcomes based on recent blood pressure recommendations.
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Do Antibiotics Reduce Hormonal Contraceptive Effectiveness?
Researchers conducted a systematic review of studies that evaluated the effect of concomitant non-rifamycin antibiotic use on hormonal contraceptive effectiveness. Although data are limited, there was no evidence to support the existence of drug interactions.