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Value of Liver Function Tests in Cardiogenic Shock

A prospective, multicentered, observational study of patients admitted with cardiogenic shock showed that a > 20% rise in alanine aminotransferase in the first 24 hours is associated highly and independently with 90-day mortality.

Risk of Major Bleeding With Concurrent Medications in Atrial Fibrillation Patients Taking New Oral Anticoagulants

A large nationwide comprehensive clinical database showed that concomitant use of the new oral anticoagulants with amiodarone, fluconazole, rifampin, and phenytoin increases the risk of major bleeding.

ORBITA: Learning the Right Lessons From a Sham-controlled Trial of Angioplasty

In this sham-controlled trial of 200 patients with single-vessel coronary artery disease and stable angina, percutaneous coronary intervention did not increase exercise time significantly compared to a placebo procedure.

Fluticasone Furoate, Umeclidinium, and Vilanterol Inhalation Powder (Trelegy Ellipta)

Trelegy Ellipta is indicated for the long-term maintenance treatment of patients with COPD, including chronic bronchitis and/or emphysema.

Clinical Briefs

In this section: Some good news for type 2 diabetes patients; hormone replacement during menopause; and chasing an unusual rosacea lead.

Functional Outcomes After Receiving Life-sustaining Therapy in the ICU

Among patients who have spent at least three days in an ICU and required even brief mechanical ventilation and/or vasopressor support, almost half are dead and only one-third return to their baseline at six months. Several factors present on the first day of admission are associated with not returning to baseline status.

Irritable Bowel Syndrome, Constipation, and Quality of Life in Women

Irritable bowel syndrome has a negative effect on women’s quality of life and affects one-third of women who present for care with fecal incontinence.

Antibiotics and Adverse Events: Doctors, Do No Harm

A retrospective study found that among 1,488 hospitalized patients who received an antibiotic, 298 experienced at least one antibiotic-associated adverse drug event. Furthermore, 287 of the antibiotic regimens were not clinically indicated, and 56 of these were associated with an adverse drug event.

Update on Postpartum Hemorrhage

In the United States, postpartum hemorrhage accounts for 11.4% of maternal deaths, the fourth most common cause after cardiovascular diseases, non-cardiovascular diseases, and infection; worldwide, it is the leading cause of maternal mortality. This feature will discuss the latest treatments for managing postpartum hemorrhage.

Hormone Replacement: Have We Made Progress Since WHI?

Vaginal estrogen may improve vaginal symptoms of menopause and does not increase the risk for endometrial cancer, stroke, or cardiovascular disease.