Clinical
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CT Calcium Score vs. Stress Testing
A subgroup analysis of the PROMISE trial showed that CT coronary calcium scores in symptomatic patients at low to intermediate risk for coronary artery disease are more sensitive but less specific for major adverse cardiac events over a two-year follow-up period than stress testing. Consequently, both approaches exhibited similar but modest discriminatory ability.
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Patent Foramen Ovale Closure Falls Short in Treatment of Migraines
This randomized trial of patent foramen ovale closure in severe refractory migraine showed no significant difference in responder rate compared to sham control.
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Cardiac MRI Most Valuable Test for Diagnosis and Prognosis in Cardiac Sarcoidosis
Among patients with extracardiac sarcoidosis, cardiac MRI was the best test for diagnosing cardiac involvement and the strongest independent predictor of adverse outcomes.
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ARNI Therapy Associated With Reduction in Ventricular Arrhythmias
In patients with congestive heart failure due to reduced ejection fraction who underwent remote arrhythmia monitoring via an implantable cardioverter defibrillator (ICD), both ventricular arrhythmias and appropriate ICD shocks were reduced while on sacubitril-valsartan compared to an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker alone.
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Does Postpartum Use of Hormonal Contraception Increase Risk of Depression?
An analysis of a large insurance database showed no consistent effect between postpartum initiation of hormonal contraception and the subsequent diagnosis of depression.
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Should Endocervical Curettage Be Performed Routinely During Colposcopy?
In this study, routine endocervical curettage (ECC) among women age 30 and older detected CIN 2 or worse in 14.4% of cases with higher likelihood of detection among women with high-grade squamous intraepithelial lesion, ASC-H, positive HPV 16 infection, or high grade colposcopic impression. The additional yield of ECC over lesion-directed ectocervical biopsies decreased with each additional biopsy.
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Dating Pregnancy: What Is the Most Accurate Method?
The NICHD Fetal Growth Studies – Singletons investigation recently yielded a new formula for determining gestational age based on standard biometric information. When compared to an often-used formula, it appeared to be more accurate after 21 weeks of gestation.
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What Do the Urinary Microbiota and Incontinence Have to Do With Each Other?
Increased diversity of the microbiota in women is associated with urgency urinary incontinence symptoms but not with stress urinary incontinence symptoms.
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Clinical Briefs
In this section: considering cardiorespiratory fitness and mortality; searching for answers on knee osteoarthritis; and comprehensive treatment for atopic dermatitis.
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Abemaciclib Tablets (Verzenio)
Abemaciclib is indicated in combination with fulvestrant for the treatment of women with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy.