Clinical
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Does Warfarin Prevent Cancer?
The finding that warfarin lowers the risk of cancer is plausible because warfarin inhibits AXL receptor tyrosine kinase-dependent tumorigenesis and enhances antitumor immune responses, even at doses below anticoagulation levels.
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Direct-acting Oral Anticoagulants vs. Warfarin in Atrial Fibrillation
Direct-acting oral anticoagulants are superior to warfarin for stroke prevention in atrial fibrillation, according to a new review.
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Is Ibuprofen Plus Acetaminophen as Effective as Opioids?
The authors of a recent analysis concluded that for patients presenting to the ED with acute extremity pain, there were no statistically significant or clinically important differences in pain reduction at two hours among single-dose treatment with ibuprofen and acetaminophen or three different opioid/acetaminophen combination.
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How Would You ‘Date’ This Infarct?
The ECG in the figure was obtained from a 48-year-old man who presented to the ED with a three-day history of chest discomfort. It clearly shows evidence of infarction. How would you “date” the infarct?
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Clinical Briefs
In this section: A new Parkinson's treatment, type 2 diabetes treatment, and morphine for dyspneic acute heart failure patients.
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Zoster Vaccine Recombinant Adjuvanted (Shingrix)
Shingrix is indicated for the prevention of herpes zoster in adults ≥ 50 years of age.
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Fecal Microbiota Testing
Researchers have determined that persons with diabetes or inflammatory bowel disease — or people who have received recent antibacterial therapy — may exhibit very different microbiota profiles. Unfortunately, no one really knows what these differences mean in terms of your overall health.
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Is a Dabigatran Reversal Agent Effective?
A pragmatic clinical study of idarucizumab for counteracting the effects of the oral anticoagulant dabigatran showed rapid and complete reversal of its effects in patients with major bleeding or urgent surgery, without any adverse safety concerns.
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Can Medical Therapy Improve Functional Mitral Regurgitation?
Among patients who presented with heart failure with reduced ejection fraction and severe functional mitral regurgitation, mitral regurgitation improved in 38% of patients with medical management. Improvement in mitral regurgitation was associated with increased survival.
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New Rules Undermine Federal Contraceptive Coverage Guarantee
The regulations leave the coverage guarantee in place, but greatly extend exemptions.