Cardiology
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Testing Safety, Efficacy of Pharmacotherapy in Hospitalized Heart Failure Patients
In patients hospitalized for acute decompensated heart failure with reduced ejection fraction, administering sacubitril-valsartan led to more improvement in levels of cardiac biomarkers compared to enalapril, with no adverse safety signals.
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PCSK9 Inhibitors in Acute Coronary Syndrome Patients
Compared to adding placebo, using the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab in post-acute coronary syndrome patients on maximally tolerated, high-intensity statins with low-density lipoprotein (LDL) cholesterol levels higher than 70 mg/dL lowered LDL and reduced the number of major adverse cardiac events.
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Omadacycline Injection and Tablets (Nuzyra)
The FDA has approved a broad-spectrum antibiotic for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections.
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Nocturia: Does Salt Intake Play a Role?
Researchers suggest that excessive salt intake can contribute to urinary frequency and nocturia.
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Exercise Improves Physical Function in Patients With Knee Osteoarthritis
Tailored exercise therapy can improve physical functioning in patients with knee osteoarthritis and comorbid conditions.
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Limited English Proficiency Associated With Significant Differences in End-of-Life Care
In a retrospective cohort study, patients with limited English proficiency had lower rates of do not resuscitate orders, comfort measures orders, and advance directives; higher rates of receiving certain types of life support; and longer hospital stays compared to their English-speaking counterparts.
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The Mediterranean Diet Keeps the Mind Sharp
Italian seniors who ate a high-quality Mediterranean diet exhibited better cognitive function than those who did not.
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Early Rehospitalization Among ICU Survivors: How Can We Do Better?
Based on inductive analysis of a large sample of patients and caregivers, this study provides an organizational framework on which to focus efforts to develop complex healthcare interventions aimed at reducing readmission after critical illness.
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Diagnosis Sepsis: Is Newer Better?
Sepsis-3 criteria may be the favored method for prognostication, whereas SIRS-based criteria may be the preferred method to screen patients for consideration of ICU admission. Future studies are necessary to continue to explore the benefits of qSOFA and potentially reveal a more precise and reliable screening tool. Most importantly, it is paramount to remember that neither set of criteria is diagnostic. Using clinical judgment along with these guides remains the ideal approach.
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A Combination of Commonly Measured Clinical Variables May Predict Prolonged Mechanical Ventilation
The results of this study validate a clinical tool using common ICU variables for predicting prolonged mechanical ventilation. However, one must consider both the implications and strength of any predictive model for clinical decision-making.