Articles Tagged With: antibiotics
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Antibacterial Therapy in the Critically Ill
Appropriate antibiotic therapy in the critically ill requires consideration of important patient-specific factors, such as antibiotic therapy in the preceding 30 days; culture and sensitivity data, if available, within the prior six months; and local resistance patterns.
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Comparison of Postoperative Antibiotic Regimens for Complex Appendicitis: Is Two Days as Good as Five Days?
In a pragmatic, open-label, randomized trial conducted at 15 hospitals in the Netherlands, two days of postoperative intravenous antibiotics for complex appendicitis was found to be noninferior to five days in terms of infectious complications and mortality within 90 days.
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A Rapid Molecular Test Improves Time to Appropriate Therapy and Mortality in Patients with CRE Bacteremia
A multicenter observational study of patients with carbapenem-resistant Enterobacterales bacteremia found that time to receipt of active antibiotic therapy and mortality were improved in those whose blood cultures underwent rapid molecular testing for the Klebsiella pneumoniae carbapenemase gene. The mortality rate was 10% with ceftazidime-avibactam compared to 31% with polymyxin monotherapy.
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A Comparison of Ceftaroline and Daptomycin in the Treatment of MRSA Bloodstream Infections
Ceftaroline is an acceptable alternative therapy for treatment of methicillin-resistant Staphylococcus aureus bacteremia.
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Antibiotic Resistance: We Were Doing Great and then COVID Happened
After improvement, antimicrobial resistance in the United States significantly increased.
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Macrolides and Hearing Loss — A Risk for Children?
In a large U.S. population group, use of short-term oral azithromycin was associated with an increased risk of sensorineural hearing loss.
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COVID-19 Exacerbated Antimicrobial Resistance
CDC report indicates related infections and deaths rose 15% in hospitals in 2020.
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To Bolster Antibiotic Stewardship, Refine Culture Follow-Up Process
Appoint a dedicated person who sifts through culture reports, reviews old culture data, and follows up with patients. Ideally, this person would be an expert around the antibiotic spectrum who could tailor therapy to culture results.
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Experts Urge ED Leaders to Refocus Efforts on Antimicrobial Stewardship
Early advocates of antimicrobial stewardship tended to focus on prescribing in outpatient settings. In recent years, attention has shifted toward the ED — and there are many good reasons for this shift.
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Too Many Antibiotics May Affect Vaccine Response Among Infants, Toddlers
Remain cautious about overprescribing antibiotics.