Articles Tagged With: antibiotics
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Cephalexin Beat Cefdinir for Treating Uncomplicated UTI in Women
Cefdinir was inferior to cephalexin in the treatment of uncomplicated urinary tract infections in women due to a high rate of early recurrence.
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Computerized Order Entry Reduces Antibiotic Use in Low-Risk Patients Hospitalized with SSTIs
A cluster randomized clinical trial assessed the effect of an antibiotic stewardship bundle that included computerized provider order entry (CPOE) prompts vs. routine stewardship on antibiotic selection during the first three hospital days in noncritically ill adults hospitalized with skin and soft tissue infections. CPOE prompts significantly reduced use of extended-spectrum antibiotics without increasing admissions to intensive care units or hospital length of stay.
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Postoperative Antibiotics After Cesarean Delivery to Reduce SSI
This randomized, double-blind clinical trial including 321 women with a pre-pregnancy body mass index > 30 kg/m2 demonstrated no difference in surgical site infection composite between participants receiving oral cephalexin and metronidazole for 48 hours after cesarean delivery compared to placebo (5.6% vs. 6.8%; odds ratio, 0.80; 95% confidence interval, 0.33-2.22; P = 0.64).
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In Vitro Activity of Newer Antibiotics Against CREs in the United States
The activity of newer beta-lactam/beta-lactamase combination antibiotics depends on the specific type of carbapenemase carried by carbapenem-resistant Enterobacterales.
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Patients Hospitalized for Non-Severe COVID-19: No Benefit of CAP Antibiotics
A large population-based, retrospective, cohort study found there was no benefit for antibiotics targeting community-acquired pneumonia in patients hospitalized with non-severe COVID-19. These results provide evidence against antibiotic use in this population.
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Patients Hospitalized for Nonsevere COVID-19: No Benefit of CAP Antibiotics
A large population-based, retrospective, cohort study found there was no benefit for antibiotics targeting community-acquired pneumonia in patients hospitalized with nonsevere COVID-19. These results provide evidence against antibiotic use in this population.
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Early Preoperative Antibiotics Before Appendectomy
Pre-incision treatment did not reduce intra-operative perforation, and likewise did not change purulent contamination, peri-appendicular abscess, or histologic gangrene. It did lower 30-day surgical-site infection (SSI) (1.6% vs. 3.2%; P = 0.03) and re-intervention for SSI (0.3% vs. 1.1%), but the effect was marginally significant, giving a number-needed-to-treat of 63 for any SSI and 125 for a re-intervention.
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Antibiotics for Asymptomatic Bacteriuria: Using Urinalysis to Improve Stewardship
A cohort study found that in patients receiving antibiotics for a urinary tract infection, a urinalysis with pyuria and/or nitrituria identified 40% more cases of unnecessary antibiotic use compared to asymptomatic bacteriuria.
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Antibiotics for Asymptomatic Bacteriuria: Using Urinalysis to Improve Stewardship
A cohort study found that in patients receiving antibiotics for a urinary tract infection, a urinalysis with pyuria and/or nitrituria identified 40% more cases of unnecessary antibiotic use compared to asymptomatic bacteriuria.
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Antibiotics for Asymptomatic Bacteriuria: Using Urinalysis to Improve Stewardship
A cohort study found that in patients receiving antibiotics for a urinary tract infection, a urinalysis with pyuria and/or nitrituria identified 40% more cases of unnecessary antibiotic use compared to asymptomatic bacteriuria.