Articles Tagged With: antibiotics
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Shigella: The New Superbug?
Five percent of Shigella isolates in the United States in 2022 were extensively drug-resistant.
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Incentivizing New Antibiotics to Kill Multidrug-Resistant Bugs
Bacteria have developed resistance to so many antibiotics that a familiar adage about these lifesaving drugs is “use ’em and lose ’em.” Ideas to break this cycle and create a market for new antibiotics include the proposed PASTEUR (Pioneering Antimicrobial Subscriptions To End Upsurging Resistance) Act of 2023, which has been reintroduced in Congress.
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First-Choice Antibiotic for Acute Bacterial Sinusitis in Children
Review of a large database reveals that, for children treated for acute sinusitis, amoxicillin and amoxicillin-clavulanate yield similar rates of treatment failure. However, medication side effects are more common when amoxicillin-clavulanate is used.
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Antibiotic Stewardship vs. Diagnostic Stewardship for Reducing Unnecessary Antibiotics in Asymptomatic Bacteriuria
A statewide quality study compared antibiotic stewardship to diagnostic stewardship for hospitalized patients with asymptomatic bacteriuria. It found that reducing urine cultures decreased unnecessary antibiotic prescribing better than antibiotic stewardship.
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Duration of Antibiotic Therapy for Carbapenem-Resistant Enterobacterales Bacteremia
This multicenter, observational study provides the first focused comparison of short vs. prolonged antibiotic courses for carbapenem-resistant Enterobacterales bloodstream infections, suggesting that short courses (eight to 10 days) have similar outcomes to prolonged courses.
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Oral Antibiotics in Endocarditis: Hitting the Target
Pharmacodynamic/pharmacokinetic analysis of patients in the POET study provides understanding of the efficacy of intravenous-to-oral stepdown antibiotic therapy in patients with endocarditis.
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What Is the Optimal Duration of Antibiotics for a Complicated UTI with Bacteremia?
An observational study of adults hospitalized with a complicated urinary tract infection and bacteremia revealed seven days of therapy was enough for most cases when they received antibiotics with comparable intravenous and oral bioavailability.
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What Is the Optimal Duration of Antibiotics for a Complicated UTI with Bacteremia?
An observational study of adults hospitalized with a complicated urinary tract infection and bacteremia found seven days of therapy was enough for the majority of cases when they received antibiotics with comparable intravenous and oral bioavailability.
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Scientists Use Artificial Intelligence While Searching for ‘Superbug’ Solutions
Researchers enlisted the help of technology to find an antibiotic that could fight multidrug-resistant bacteria.
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Inappropriate Antibiotic Prescribing Is Common for Elective Surgeries
A retrospective cohort study of adults who underwent an elective craniotomy, hip replacement, knee replacement, spinal procedure, or hernia repair revealed only 59% adhered to recommended guidelines on prophylactic antibiotic prescribing. Unnecessary vancomycin use was the most common reason for nonadherence and had 19 times higher risk for acute kidney injury.