Articles Tagged With: antibiotics
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Pink Eye: Do Antibiotics Matter?
Acute infectious conjunctivitis, commonly referred to as pink eye, is common in children and is caused by bacteria more often than by viruses. Nonetheless, neither the clinical course of uncomplicated cases nor the spread of infection to peers is significantly altered by treatment with topical antibiotics or by exclusion of infected children from daycare and school settings.
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Effectiveness and Safety of Transitioning to Oral Antibiotics in Solid Organ Transplant Recipients with Uncomplicated Gram-Negative Bloodstream Infection
In a retrospective observational study, transitioning to oral antibiotics was demonstrated to be as effective and safer in solid organ transplant recipients with uncomplicated gram-negative bacteremia as compared with completion of therapy with intravenous antibiotics.
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Beta-Lactam Antibiotics Administered via Prolonged Infusions Lead to Lower Mortality Risk Compared to Intermittent Infusions
In a systematic review and meta-analysis, the administration of beta-lactam antibiotics by prolonged infusions was associated with a significantly reduced risk of mortality at 90 days for critically ill patients with sepsis or septic shock as compared with intermittent infusions.
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Antibiotic De-Escalation Can Decrease the Development of Antibiotic Resistance in Gram-Negative Bacteria
A retrospective cohort study found that de-escalation of broad-spectrum beta-lactam agents in patients with sepsis significantly reduced the subsequent development of antimicrobial resistance in gram-negative bacteria isolated from clinical cultures.
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Newer Antibiotics for Resistant Gram-Negative Infections: Why Are Clinicians Not Using Them?
A retrospective cohort study on adult inpatients with difficult-to-treat resistant pathogens found clinicians used older, generic antibiotics with suboptimal safety profiles in almost 80% of cases.
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Inappropriate Diagnosis of Pneumonia Is Common in Hospitalized Patients
A cohort study that included 48 hospitals in Michigan found that 12% of patients treated for community-acquired pneumonia were diagnosed inappropriately. Older age, dementia, and presenting with acute change in mental status increased the risk for misdiagnosis.
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Fidaxomicin vs. Oral Vancomycin for Clostridioides difficile Infection in Patients Receiving Concomitant Antibiotics
This open-label, randomized trial of patients with Clostridioides difficile infection receiving concomitant antibiotics found no difference in clinical cure between fidaxomicin and oral vancomycin.
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The IP Role in Sepsis
The Centers for Disease Control and Prevention has issued core elements for hospital sepsis programs, calling for a multidisciplinary team to prevent, detect, and treat these life-threatening systemic breakdowns.
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New Sepsis Rule Puts Teeth Behind the SEP-1 Bundle, Putting Revenue at Risk for Providers Who Fail to Meet Benchmarks
A coalition of large healthcare associations, including the American College of Emergency Physicians, is taking issue with a new rule from the Center for Medicare & Medicaid Services that will require hospitals to meet the provisions outlined in the Severe Sepsis/Septic Shock Management Bundle, a series of labs, measurements, and therapies often referred to as SEP-1.
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Antibiotic Stewardship vs. Diagnostic Stewardship for Reducing Unnecessary Antibiotics in Asymptomatic Bacteriuria
A statewide quality study compared antibiotic stewardship to diagnostic stewardship for hospitalized patients with asymptomatic bacteriuria. It found that reducing urine cultures decreased unnecessary antibiotic prescribing better than antibiotic stewardship.