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Can You Be Certain?
You are asked for your opinion on this electrocardiogram (ECG). No history is available. Can you be certain of your diagnosis?
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Remibrutinib Tablets (Rhapsido)
The U.S. Food and Drug Administration has approved a second Bruton’s tyrosine kinase inhibitor (BTKi), remibrutinib, for the treatment of chronic spontaneous urticaria (CSU) in adults who remain symptomatic despite antihistamine treatment. The first BTKi, rilzabrutinib (Wayrilz), was approved for chronic immune thrombocytopenia. Remibrutinib is distributed by Novartis Pharmaceuticals Corporation as Rhapsido.
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Spironolactone for the Treatment of Acne Vulgaris
In this meta-analysis of 563 patients from five randomized controlled trials, objective assessment of acne improvement was higher in the spironolactone group compared to the placebo group (odds ratio, 6.59; 95% confidence interval, 3.50-12.43).
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Cephalexin Beat Cefdinir for Treating Uncomplicated UTI in Women
Cefdinir was inferior to cephalexin in the treatment of uncomplicated urinary tract infections in women due to a high rate of early recurrence.
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Comprehensive Data Analysis Validates the Effectiveness and Safety of COVID-19, RSV, and Influenza Vaccination
Respiratory syncytial virus, influenza, and COVID-19 vaccines are safe and effective.
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Ablation vs. Drugs for Ventricular Tachycardia
A sub-analysis of the VANISH2 trial, which compared catheter ablation (CA) to antiarrhythmic drug therapy for the suppression of ventricular tachycardia (VT) in patients with ischemic cardiomyopathy has shown that in the sotalol therapy group, those randomized to CA less frequently experienced the VT-based composite endpoint. Conversely, in the amiodarone group, the primary endpoint was similar in the CA- and drug therapy-randomized patients, but amiodarone produced more adverse events.
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Knee Osteoarthritis and Degenerative Meniscal Tear: Lessons from Two 2025 Trials
Two high-quality, randomized studies demonstrate the effectiveness of unsupervised exercise programs for knee osteoarthritis and degenerative menisical tear.
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Acute Aortic Dissection
Acute aortic syndromes, such as dissection, ulcers, or intramural hematomas, are infrequent presentations with a high rate of mortality. While each has a described classic presentation, the absence of these findings is not reliable to adequately exclude the diagnosis and, thus, they provide a significant challenge to emergency clinicians.
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Iatrogenic Cerebral Amyloid Angiopathy-Related Inflammation
In this multicenter, retrospective case series, the authors sought to describe the co-occurrence of two rare variants of cerebral amyloid angiopathy: iatrogenic cerebral amyloid angiopathy, thought to be caused by prion-like spread of amyloid beta after seeding from neurosurgical procedures decades prior to symptom onset, and cerebral amyloid angiopathy-related inflammation, characterized by robust perivascular inflammatory response in amyloid-laden vessels. This series demonstrates that inflammation can complicate iatrogenic cerebral amyloid angiopathy, supporting a spectrum model of disease and urging multicenter study.
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Vertigo and Altered Postural Perception: Overlapping Symptoms, Distinct Mechanisms
Two distinct vestibular disorders, persistent postural-perceptual dizziness (PPPD) and vestibular migraine (VM), both involve vertigo as a primary symptom. Nearly half of chronic migraine patients also experience vertigo, especially those with aura and allodynia. Since PPPD is seen as a functional maladaptation and VM is associated with cortical hyperexcitability, treatment for vertigo in these two conditions should be tailored to their unique pathophysiological mechanisms.