OB/GYN Clinical Alert
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Please complete our annual reader survey (https://bit.ly/2XYHWdM).
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Malaria Prophylaxis During Pregnancy
In a retrospective study of American military women involving 50 treated with atovaquone-proguanil and 156 exposed to mefloquine, no increase in risk of fetal loss or adverse infant outcomes was identified. Atovaquone-proguanil seems safe for use in pregnancy, but data are limited.
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Many Serious Cardiac Complications of Pregnancy Are Preventable
Investigators determined about half of serious cardiac complications of pregnancy are preventable.
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Macrolides During Pregnancy — Behind the Headlines
Despite published concerns, there is no good evidence that macrolide use during pregnancy causes birth defects.
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Is Nitrous Oxide an Effective Analgesic During Labor?
In this prospective cohort study at one large academic medical center in Colorado, 31% of women who opted for nitrous oxide for analgesia during labor did not require any other source of analgesia, such as an epidural or intravenous opioids. Risk factors for conversion to other modalities included labor induction, oxytocin augmentation, and labor after cesarean.
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We’d Love to Hear From You!
Please complete our annual reader survey (https://bit.ly/2XYHWdM).
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A Note from OB/GYN Clinical Alert’s New Editor
Rebecca Allen, MD, MPH, begins role as editor.
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A New Treatment for Recurrent Bacterial Vaginosis?
In this randomized, controlled trial of 228 women, Lactobacillus crispatus CTV-05 (Lactin-V) applied vaginally for 11 weeks reduced the incidence of recurrent bacterial vaginosis from 45% in the placebo arm to 30% in the Lactin-V arm.
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Fezolinetant Shows Positive Response in Vasomotor Symptoms Associated with Menopause
A phase 2b trial using seven dosing regimens of a novel neurokinin-3 receptor antagonist, fezolinetant, shows statistically significant improvement in vasomotor symptoms vs. placebo in postmenopausal women.
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Does a Standardized Recovery Bundle After Cesarean Delivery Decrease Length of Stay?
Implementation of an enhanced recovery bundle after cesarean delivery reflected diverse positive outcomes. However, length of stay was reduced only by an average of two hours.