Neurology
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The Pulmonary Embolism Rule-out Criteria in Low-risk Patients
A cluster randomized trial of the pulmonary embolism rule-out criteria (PERC) compared to usual care for patients estimated to be at low risk of pulmonary embolus (PE) in EDs showed that PERC was non-inferior to usual care at identifying patients who would be free of symptomatic PE at three months, resulting in less use of healthcare resources.
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Anti-MAG Antibodies: Clinical and Therapeutic Aspects
Anti-MAG antibody-associated neuropathy may present as many disorders, including small fiber neuropathy, sensorimotor neuropathy, Guillain-Barré-like syndrome, and multifocal motor neuropathy. Rituximab appears to be the best therapeutic option.
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Longitudinal tau PET as an Outcome Measure for Clinical Trials
tau PET imaging shows progression of brain Alzheimer’s pathology over time and correlates with cognitive impairment better than amyloid PET. In future clinical trials, tau PET can serve as a biomarker for Alzheimer’s disease progression.
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What Are the Early Predictors for Post-traumatic Epilepsy After Injury?
Following traumatic brain injury, early (first five days after injury) epileptiform abnormalities on EEG were seen more commonly in patients with subsequent post-traumatic epilepsy (PTE), compared to controls, and were found to be a significant and independent predictor of PTE. The presence of subdural hemorrhage was the only other independent predictor of PTE.
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Intracranial Pressure Changes in Mild Traumatic Brain Injury
After an exhaustive review of the animal and human studies literature regarding mild traumatic brain injury (mTBI), Haider et al. did not reach consistent conclusions regarding evidence for intracranial pressure elevation in human patients who sustain an mTBI.
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Prediction of Persistent Post-concussion Symptoms After Mild Traumatic Brain Injury
Persistent post-concussion syndrome may last for more than six months, and risk factors include female sex, neck pain, headache, and post-concussive symptoms at two weeks after the injury.
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Fostamatinib Disodium Hexahydrate Tablets (Tavalisse)
Fostamatinib is indicated for the treatment of thrombocytopenia in adults with chronic immune thrombocytopenia with insufficient response to a previous treatment.
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Running and Health
In a review and meta-analysis of the effects of running and longevity, researchers concluded that running provides specific and significant health benefits and proposed a threshold above which more running provides diminishing returns.
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Sleep Habits and the Development of Dementia
The relationship between quality of sleep and the development of dementia is controversial and not yet clearly elucidated nor understood.
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Neurogenesis in Older, Healthy Brains
Healthy aging allows for hippocampal neurogenesis in the brains of adults into the eighth decade of life.