Neurology
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Predicting Future Dementia With Retinal Optical Coherence Tomography
Optical coherence tomography (OCT) is an innovative imaging device that measures thickness of retinal nerve fiber layers and ganglion cells. Thinning of these layers is associated with current and future risk of dementia.
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Use of Amyloid PET Imaging for Diagnosis of Dementia
The use of amyloid positron emission tomography scanning to assist in accurate diagnosis of patients with symptoms of cognitive impairment as well as frank dementia results in a change of diagnosis in at least 25% of patients.
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Viral Therapy for Glioblastoma
In a Phase I/II trial, convection-enhanced delivery of an engineered poliovirus yielded similar median overall survival compared to historical controls. However, a small subgroup of treated patients had extended survival past two years.
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Are Oral Corticosteroids as Effective as Intravenous Steroids in the Treatment of Acute Optic Neuritis?
Based on outcomes measured at one and six months following optic neuritis in the context of multiple sclerosis, these investigators reported similar efficacy when comparing oral to bioequivalent doses of intravenous steroids.
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Avatrombopag Tablets (Doptelet)
Doptelet is prescribed for adults with thrombocytopenia and chronic liver disease who are scheduled to undergo a medical procedure.
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‘The World Is Covered by a Thin Layer of Feces’
This study mirrors earlier work in New York City, which found that sand boxes and dog play areas often are contaminated with C. difficile.
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Oral Antibiotics May Increase the Risk for Nephrolithiasis
A case-control study found that receipt of an oral antibiotic in the preceding three to 12 months was associated with nephrolithiasis. The risk persisted up to five years, and younger patients were at increased risk.
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Does Childhood Adversity Affect the Menopausal Transition?
The number and timing of adverse childhood experiences in relation to puberty affect the risk of incident major depressive disorder in menopausal transition.
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Simple Prediction Tool Facilitates Diagnosis of Heart Failure With Preserved Ejection Fraction
In patients with unexplained dyspnea, a score based on six noninvasive criteria can predict the likelihood of heart failure with preserved ejection fraction.
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An Uncommon Cause of ST Elevation?
Are the ST-T wave abnormalities seen in the tracing with this article the result of early repolarization? Or is this likely to represent acute pericarditis?