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While hypertension and smoking have been previously associated with aneurysmal subarachnoid hemorrhage, this is the first report of a role for coffee consumption. The methodology of the study, however, begs several further questions.
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In an extremely preliminary report, Mayer and associates present data on 5 patients with basilar artery thromboses treated with a device called Neuronet.
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Multiple system atrophy (MSA) is a neurodegerative disorder that can take protean forms. In this elegant paper, Tsuda and colleagues show that patients with the cerebellar form of MSA can be distinguished from idiopathic cerebellar degeneration before other signs of autonomic or parkinsonian disability develop.
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Metman and associates carried out a controlled trial using amantadine to determine whether they could ameliorate chorea. This was based on prior studies showing that N-methyl-D-aspartate antagonists such as dextrophan, dextromethorphan, and amantadine can alleviate levodopa-induced chorea inpatients with parkinsonism.
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Serial MRI measurements can be used to map the pattern of regional brain atrophy in a variety of neurologic disease states. Using robust techniques that minimize the subjectivity of morphometric analysis, Scahill and colleagues compared rates and regional distribution of brain atrophy in 4 presymptomatic patients, 10 with mild Alzheimers Disease (AD), 12 with moderate AD, and age-matched controls.
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MRC/BHF Heart Protection Study of Antioxidant Vitamin Supplementation in 20,536 High-Risk Individuals; Prolonged Erections Produced by Dihydrocodeine & Sildenafil; Effect of Magnesium Supplementation of Blood Pressure; Homocysteine-Lowering Therapy with Folic Acid, Vitamins, and Clinical Outcome after Percutaneous Coronary Intervention; Effect of Cataract Surgery on Motor Vehicle Accidents in Older Adults; Inflammatory Biomarkers, Hormone Replacement Therapy, and Incident Coronary Heart Disease
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The ISAT trial enrolled 2143 patients, primarily in Britain, with ruptured intracranial aneurysms and randomly assigned them to neurosurgical clipping or GDC coils. The results add another nail into the coffin of neurosurgical clipping.
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Diabetic painful sensory neuropathy remains difficult to treat. In this randomized, double-blind, placebo-controlled trial, sodium valproate was administered to 30 patients with efficacy and safety compared to 30 placebo-control patients.
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Schindler and colleagues in Munich evaluated whether visual exploration training alone or in combination with electromechanical vibration of the left neck muscles of patients while they engaged in visual search exercises were effective techniques for the rehabilitation of spatial neglect.
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There is substantial evidence that mitochondrial defects and oxidative damage play a role in the pathogenesis of Parkinsons disease.
