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FDA warning on topical anesthetics; antipsychotics increase sudden cardiac death; the step up vs step down debate; treating pain, fatigue, mood, and sleep in fibromyalgia; FDA Actions.
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Telcagepant, a new oral calcitonin gene-related peptide receptor antagonist, has similar efficacy and better tolerability for acute migraine headaches as compared to a triptan.
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Sleep disordered breathing occurs in most acute stroke patients and may contribute to morbidity
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Great progress has been made in identifying the underlying genetic defects in congenital myopathies.
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Chronic treatment with warfarin, prior to presentation with an ischemic stroke, is associated with a significant decrease in infarct size.
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Mesial temporal sclerosis is the most common pathology found in surgical series of patients undergoing temporal lobectomy for pharmacologically intractable focal epilepsy. A better understanding of the mechanisms leading to this neuropathological substrate for temporal lobe epilepsy should provide fundamental insights into the pathophysiology of epileptogenesis.
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Although syncope is common, its epidemiology and prognosis have not been well described. Soteriades and colleagues, therefore, evaluated the incidence, causes, and prognosis of syncope among men and women taking part in the Framingham Heart Study.
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The high lifetime prevalence of depression in MS, along with other variants of mood disorder including anxiety and bipolar-affective illness, should make the psychiatric complications of MS a central component of disease management. These studies provide an additional understanding of depression and suicidal behavior in patients with MS.
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No single antigen has yet been identified as the target in all patients with chronic inflammatory demyelinating polyneuropathy, a presumed autoimmune disorder similar to chronic experimental allergic neuritis, where both humoral and cell-mediated immune responses have been documented. Evidence suggests that specific chemokines play a role in pathogenesis.
