Browse Neurology Alert Articles by Topic

Mechanisms of Tissue Hypoxia and Cerebral Ischemia in Traumatic Brain Injury

Tissue hypoxia after traumatic brain injury occurs in a widespread manner in the brain, including areas that appear structurally normal. Moreover, cerebral tissue hypoxia appears to occur independent of ischemia with areas of no overlap, implying a microvascular etiology.

Sleep Disorders Associated with Traumatic Brain Injury

Patients with traumatic brain injuries need longer sleep times to heal the injured brain, and persistent pleiosomnia at 18 months implies that ongoing abnormalities are producing an increased need for sleep.

Eating Behavior in Frontotemporal Dementias

In a prospective, controlled study of 49 patients with dementia and 25 healthy controls, marked hyperphagia is restricted to behavioral-variant frontotemporal dementia patients that is likely due to differing neural networks, while increased sucrose preference is likely controlled by a similar network in both behavioral-variant frontotemporal dementia and semantic dementia patients.

Migraine with Aura and Systemic Right-to-Left Shunt: Risk for Stroke?

Right-to-left shunts, as detected by transcranial Doppler, are more common in patients with migraine with aura, but are not correlated with increased risk of silent posterior circulation infarcts or white matter lesions on MRI.

Leigh Syndrome: Insights and Implications from Advances in Next-generation Sequencing

Leigh syndrome is a genetically heterogeneous neurodevelopmental disorder. The application of next-generation sequencing has enabled a deeper understanding of the diverse nature of the genetic and molecular etiologies that give rise to the shared clinical phenotype of Leigh syndrome.

Differentiating Sarcoidosis from Neuromyelitis Optic in Patients with Transverse Myelitis

Based on a retrospective analysis of 71 patients with an neuromyelitis optica spectrum disorder (n = 37) or sarcoidosis (n = 34), whose initial presentation was longitudinally extensive transverse myelitis (≥ 3 vertebral segments), the authors report clinical, radiologic, and laboratory findings that help distinguish one from the other.

Carpal Tunnel Syndrome: Everything You Want To Know, and More

Carpal tunnel syndrome can be reliably diagnosed, only with nerve conduction studies, and this test should be performed before any invasive treatments are initiated.

Relationship Between Spikes and Seizures Using an Implantable Intracranial Detection Device

The authors report the preliminary findings for an implantable ambulatory intracranial recording device for seizure detection in 15 subjects. One of the primary findings was that spike rate significantly changed prior to seizures in nine of 15 subjects. Six of these subjects showed a significant decrease in spiking prior to ictal onset, whereas the remaining three showed a significant increase in spiking and these three subjects had the best seizure prediction results.

Clinical Characterization of Inherited Erythromelalgia Due to Sodium Channel Mutations

A detailed non-interventional clinical study of patients with inherited erythromelalgia who carry gain-of-function mutations of voltage-gated sodium channel Nav1.7 further characterized pain phenotypes in this disorder and showed wide variability of pain symptoms.

A Brief Report of Clinical Trials Results from the 2016 International Stroke Conference

This article provides an overview of the research presented at the 2016 International Stroke Conference.