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Intravenous Glyburide to Reduce Brain Swelling in Large Hemispheric Infarction

In a Phase II, randomized, multicenter prospective trial, intravenous glyburide failed to improve outcomes in patients with large hemispheric infarction, although there was a reduction in neuroimaging and biomarkers of cerebral edema.

RESCUEicp: A Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension

Decompressive craniectomy for the treatment of refractory intracranial hypertension in patients with severe traumatic brain injury reduced mortality but increased rates of vegetative states, lower severe disability, and upper severe disability compared to continued medical management.

Zika Virus Infection and Guillain-Barré Syndrome

Guillain-Barré syndrome is a defined complication of Zika virus infection and presents in a typical manner, similar to other post-viral GBS syndromes.

Headaches in the Elderly: A Non-specific Marker for Stroke Risk

Non-migrainous headaches, for which there are many causes, appear to be a risk factor for stroke in an elderly population, but the mechanism is uncertain.

Disease Rebound After Stopping Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis

A review of patients with relapsing-remitting multiple sclerosis who discontinued fingolimod therapy showed that five out of 46 (10.9 %) of these patients developed a rebound phenomenon between 4 to 16 weeks, where disease activity returns and often exceeds pre-treatment levels.

Functional Outcomes in Acute Ischemic Stroke Patients Receiving Prehospital Thrombolysis in Mobile Stroke Units

Deployment of a mobile stroke treatment unit in the field results in a higher percentage of patients treated with intravenous tPA, at a shorter interval from onset of symptoms, and results in better outcomes.

Cancer in Autoimmune Necrotizing Myositis

Immune-mediated necrotizing myopathy is a distinct syndrome that can be differentiated from polymyositis and dermatomyositis, and is commonly associated with underlying malignancy.

Triage to a Certified Stroke Center Reduces Early Mortality

In an analysis of the effect of additional travel time, receiving treatment in a primary stroke center was associated with a survival benefit for stroke patients who traveled less than 90 minutes. Traveling more than 90 minutes to reach a primary stroke center offset any benefit.

Community Education Improves Stroke Awareness and Appropriate Emergency Response

Community education programs are essential in efforts to improve overall success in treating acute ischemic stroke.

Distinct EEG Features May Help Prognostication of Patients with Early PAMM

Early post-anoxic multifocal myoclonus (PAMM) traditionally has been considered a grave prognostic feature in patients who remain comatose after cardiac arrest. This study defines distinct electrographic phenotypes in the setting of PAMM with substantially different prognostic outcomes.