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Patients with sensory-predominant neuropathy should be tested for glucose tolerance and vitamin B12 concentration.
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Pregabalin appears to be a safe and effective alternative for the treatment of painful diabetic polyneuropathy.
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In this population, deficient nutritional status may contribute to its relatively high incidence of cerebral vein thrombosis.
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CT angiography has high sensitivity and high negative predictive value for carotid disease.
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These findings provide compelling evidence in favor of the amyloid cascade hypothesis, which suggests that amyloid beta leads to the development of hyperphosphorylated tau aggregates within neurons.
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NK cells may regulate activation of autoimmune memory T cells in an antigen non-specific fashion to maintain the clinical remission in CD95(+) NK-high multiple sclerosis patients.
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Sources of funding for pharmaceutical research has come under scrutiny in the last decade as academic and government sources of funding have become increasingly scarce and the pharmaceutical industry has become the main source of research dollars. But the issue of objectivity has been raised, and some have even suggested that negative studies, that is studies that show a drug in an unfavorable light, may never be published. The American Medical Association has recently tackled this issue.
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Leflunomides immunomodulatory activity derives from its action as a competitive inhibitor of the rate-limiting enzyme necessary for pyrimidine synthesis.
