Internal Medicine Alert
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Risk of Endocarditis Revisited
The authors of a population-wide study of hospitalizations and deaths from infective endocarditis (IE) in England confirmed the high risk of IE in certain cardiac conditions, but showed that other conditions thought to be low risk also are at higher risk and found new higher-risk categories not previously identified.
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Acute Pericarditis or Something Else?
Does the ECG included with this article suggest either acute pericarditis or acute infarction? What key piece of information is missing from the history? How would you interpret the tracing?
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Tolvaptan Tablets (JYNARQUE)
Tolvaptan is indicated to slow kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease.
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Rapid Screening for Future Risk of Parkinson’s Disease Dementia
The Montreal Parkinson Risk of Dementia Scale provides a simple eight-item screening tool with high predictive value for developing Parkinson’s disease dementia.
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Combined Treatments with Medications for Hypertension and Hyperlipidemia Dramatically Reduce the Risk of Stroke
In this real-world study, fixed-dose candesartan/hydrochlorothiazide combined with low-dose rosuvastatin reduced first stroke by 44% in patients at intermediate risk of cardiovascular disease and was well tolerated, with minimum dropout of patients.
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Chiropractic Spinal Manipulation for Migraine
Chiropractic spinal manipulation offers no benefit over placebo for migraineurs.
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The Pulmonary Embolism Rule-out Criteria in Low-risk Patients
A cluster randomized trial of the pulmonary embolism rule-out criteria (PERC) compared to usual care for patients estimated to be at low risk of pulmonary embolus (PE) in EDs showed that PERC was non-inferior to usual care at identifying patients who would be free of symptomatic PE at three months, resulting in less use of healthcare resources.
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Fostamatinib Disodium Hexahydrate Tablets (Tavalisse)
Fostamatinib is indicated for the treatment of thrombocytopenia in adults with chronic immune thrombocytopenia with insufficient response to a previous treatment.
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Running and Health
In a review and meta-analysis of the effects of running and longevity, researchers concluded that running provides specific and significant health benefits and proposed a threshold above which more running provides diminishing returns.
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Sleep Habits and the Development of Dementia
The relationship between quality of sleep and the development of dementia is controversial and not yet clearly elucidated nor understood.