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Current and Future Options for Male Contraception

The following is a summary of the existing male contraceptive options and an overview of future ones.

New Therapy for Resistant Hypertension

Aprocitentan demonstrated efficacy for additional therapy beyond standard multidrug treatment in resistant hypertension.

Is It Better to Up-Titrate Medications Faster in Acute Heart Failure Patients?

Early intensive up-titration of guideline-recommended therapy in patients admitted for heart failure reduced 180-day readmission and all-cause mortality rates at the cost of more adverse events (but not serious or fatal ones).

Low-Fat vs. Mediterranean Diet for Secondary Prevention

A study of stable coronary heart disease patients comparing the Mediterranean diet to a low-fat diet over a seven-year follow-up showed the Mediterranean diet was superior at preventing major cardiovascular events.

Is AV Block Complete?

Does the ECG in the figure represent complete AV block? If not, why not?

Fecal Microbiota, live-jslm (Rebyota)

Rebyota can be prescribed to prevent recurring Clostridioides difficile infection for patients age 18 years and older who are following antibiotic treatment for recurring episodes.

Is Screening for Atrial Fibrillation Cost Effective?

Self-screening for atrial fibrillation in elderly individuals could lead to lower stroke rates, prevent bleeding-related hospitalizations, and save money.

COVID-19: Beware Remdesivir Resistance

Researchers reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in RNA-dependent RNA polymerase after remdesivir treatment.

Triglyceride-Lowering Therapy and Cardiovascular Events

Researchers studied pemafibrate vs. placebo in patients with type 2 diabetes, mild-to-moderate triglyceride elevations, and low levels of HDL and well-controlled LDL cholesterol. Despite a 31% reduction in triglyceride levels, there was no improvement in the risk of cardiovascular outcomes over a median follow-up of 3.4 years.

Is Red Meat Really Unhealthy?

A thorough review of the evidence raises questions about the health risks of eating unprocessed red meat.