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Fecal Microbiota, live-jslm (Rebyota)

Rebyota can be prescribed to prevent recurring Clostridioides difficile infection for patients age 18 years and older who are following antibiotic treatment for recurring episodes.

COVID-19: Beware Remdesivir Resistance

Researchers reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in RNA-dependent RNA polymerase after remdesivir treatment.

Infectious Disease Alert Updates

Loss of Monoclonal Therapy for COVID-19; Cost-Savings of Outpatient Antimicrobial Therapy

The Dental Procedure-Infective Endocarditis Link Controversy Continues

Infective endocarditis was more common with dental surgery or tooth extractions in the preceding four weeks in high-risk patients. Researchers abrogated this risk with antibiotic prophylaxis before the procedure.

Vaccination Against Mpox: Does it Work? Is it Safe?

Vaccination, either subcutaneously or intradermally, with the non-replicating JYNNEOS vaccine is safe and effective.

When More Is Not Better: Treatment of Prosthetic Valve Endocarditis Due to Staphylococci

Clear evidence of benefit from adjunctive administration a β-lactam and/or a glycopeptide in the treatment of prosthetic valve endocarditis due to staphylococci is lacking. Current guidelines need to be reassessed.

Resistance of SARS-CoV-2 Variants to Monoclonal Antibodies

Prevalent SARS-CoV-2 variants are increasingly resistant to therapeutic and prophylactic monoclonal antibodies but remain susceptible to Paxlovid, remdesivir, and molnupiravir.

Salmonella Gastroenteritis — The Risk of a Rapid, Accurate Diagnosis

Availability of molecular testing panel results that were positive for Salmonella in children led to increased hospital admissions, increased subsequent microbiologic testing, and increased antibiotic use — all without benefit to patients.

Statin Use with Daptomycin: Do We Finally Have a Definitive Answer?

A meta-analysis on published literature and a disproportionality analysis using Food and Drug Administration data found that statin use was associated with the occurrence of daptomycin-induced musculoskeletal adverse events. In most cases, statin use should be discontinued while patients are on daptomycin.

Ethical Justification for Research on Dangerous Pathogens

Recent inflammatory headlines suggested researchers had created a more dangerous version of COVID. However, those researchers said the headlines were misleading. Nevertheless, it spotlighted the ethical concerns involving research on pathogens.