Infectious Disease
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COVID Is Not ‘Just the Flu’
Among hospitalized patients requiring oxygen support at admission, COVID-19 was three times more fatal than was influenza.
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An Effective Oral Regimen for Rifampin-Resistant Tuberculosis
A multicenter, randomized, controlled, noninferiority clinical trial found a 24-week, all-oral regimen (bedaquiline, pretomanid, linezolid, and moxifloxacin) to be safe and effective for patients aged 15 years and older with rifampin-resistant tuberculosis.
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A Comparison of Ceftaroline and Daptomycin in Treatment of MRSA Bloodstream Infections
Ceftaroline is an acceptable alternative therapy for treatment of methicillin-resistant Staphylococcus aureus bacteremia.
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Tocilizumab Injection (Actemra)
The FDA has approved tocilizumab injection to treat COVID-19 among hospitalized adult patients who are receiving systemic corticosteroids and require supplemental oxygen.
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Physician Autonomy at Issue if Patients Demand Ineffective Treatments
A controversial Wisconsin Supreme Court case centers on whether physicians can be legally required to provide ivermectin for COVID-19 if a patient or family requests it.
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Fecal Microbiota, live-jslm (Rebyota)
Rebyota can be prescribed to prevent recurring Clostridioides difficile infection for patients age 18 years and older who are following antibiotic treatment for recurring episodes.
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COVID-19: Beware Remdesivir Resistance
Researchers reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in RNA-dependent RNA polymerase after remdesivir treatment.
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Infectious Disease Alert Updates
Loss of Monoclonal Therapy for COVID-19; Cost-Savings of Outpatient Antimicrobial Therapy
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The Dental Procedure-Infective Endocarditis Link Controversy Continues
Infective endocarditis was more common with dental surgery or tooth extractions in the preceding four weeks in high-risk patients. Researchers abrogated this risk with antibiotic prophylaxis before the procedure.
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Vaccination Against Mpox: Does it Work? Is it Safe?
Vaccination, either subcutaneously or intradermally, with the non-replicating JYNNEOS vaccine is safe and effective.