Infectious Disease
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Vaccination Against Mpox: Does It Work? Is It Safe?
Vaccination, either subcutaneously or intradermally, with the non-replicating Jynneos monkeypox vaccine is safe and effective.
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Resistance of SARS-CoV-2 Variants to Monoclonal Antibodies
Prevalent SARS-CoV-2 variants are persistently resistant to therapeutic and prophylactic monoclonal antibodies but remain susceptible to nirmatrelvir/ritonavir, remdesivir, and molnupiravir.
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Infectious Disease Alert Updates
Is Your Hospital Room Toxigenic?; Reduction of HOCDI — Gaming the System?
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Medical Masks Compared to N95 Respirators for COVID-19 Prevention in Healthcare Workers
A multicenter, randomized, controlled study found that medical masks were noninferior to N95 respirators in their relative protection against COVID-19 among healthcare workers when worn while providing routine care to patients with suspected or confirmed COVID-19.
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Inching Toward the Goal: Does Selective Decontamination of the Digestive Tract Have a Benefit for Patients on Mechanical Ventilation?
Two recent articles contribute to the ongoing discussion of whether selective decontamination of the digestive tract provides a mortality benefit for patients who are receiving mechanical ventilation.
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COVID Is Not ‘Just the Flu’
Among hospitalized patients requiring oxygen support at admission, COVID-19 was three times more fatal than was influenza.
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An Effective Oral Regimen for Rifampin-Resistant Tuberculosis
A multicenter, randomized, controlled, noninferiority clinical trial found a 24-week, all-oral regimen (bedaquiline, pretomanid, linezolid, and moxifloxacin) to be safe and effective for patients aged 15 years and older with rifampin-resistant tuberculosis.
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A Comparison of Ceftaroline and Daptomycin in Treatment of MRSA Bloodstream Infections
Ceftaroline is an acceptable alternative therapy for treatment of methicillin-resistant Staphylococcus aureus bacteremia.
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Tocilizumab Injection (Actemra)
The FDA has approved tocilizumab injection to treat COVID-19 among hospitalized adult patients who are receiving systemic corticosteroids and require supplemental oxygen.
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Physician Autonomy at Issue if Patients Demand Ineffective Treatments
A controversial Wisconsin Supreme Court case centers on whether physicians can be legally required to provide ivermectin for COVID-19 if a patient or family requests it.