Infectious Disease General
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Infectious Disease Alert Updates
Animal Reservoirs for Human Infection; Novel Rat-Derived HEV Infection in Humans; Household Contamination with Monkeypox
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Genital Herpes — No Longer Just HSV-2 as HSV-1 Makes its Move
Viral shedding after a first episode of genital herpes simplex virus type 1, which is gradually replacing herpes simplex virus type 2 as the major cause of genital infection, occurred in 12.1% at weeks 8-12 and decreased to 7.1% at the end of one year.
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Disseminated Infection Due to Neisseria gonorrhoeae
Only 0.24% of patients with gonorrhea had disseminated infection, with septic arthritis occurring in approximately one-half.
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Multi-State Tuberculosis Outbreak Due to Transmission from an Infected Bone Graft Product
An 80-year-old man with undiagnosed tuberculosis (TB) became a bone tissue donor after his death from a cardiac arrest. Bone graft product was given to 113 recipients in 20 states, of whom three died of TB. All living recipients were started on treatment for TB at a median of 69 days after bone product implementation.
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Limiting Testing in Febrile Young Infants with Abnormal Urinalyses
According to a 26-site study, febrile infants younger than 2 months of age who have abnormal urinalyses are at very low risk of having meningitis and might not necessarily need to be subjected to lumbar puncture.
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The Great Imitator Imitates Again
This case report serves as a reminder that even though pancolitis from secondary syphilis is rare, syphilitic proctitis is a not-uncommon manifestation of syphilis — and that syphilis can present as almost anything — even long COVID.
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Doxycycline Plus a Beta-Lactam to Treat Inpatients with Community-Acquired Pneumonia
In this retrospective study of an elderly male population hospitalized with community-acquired pneumonia, the combination of doxycycline with a beta-lactam was at least as effective as a respiratory fluoroquinolone or a combination of a beta-lactam with azithromycin.
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Better Diagnostics Equals Fewer Unnecessary Antibiotic Prescriptions
Researchers credit diagnostic stewardship as the top reason for an impressive reduction in needless antibiotic prescriptions.
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Infectious Disease Alert Updates
Screening for Chagas in HIV; It’s Not All About the Cough; Linezolid and Cycloserine in CSF Adequate
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Can Maternal COVID-19 Vaccination Protect Newborns?
In this case control study, 537 case infants younger than 6 months of age who were admitted to the hospital with COVID-19 were compared to 512 control infants who were hospitalized for other reasons; 16% of the case infants and 29% of the control infants had been born to mothers who had been fully vaccinated against COVID-19 during the pregnancy. The effectiveness of maternal vaccination against infant hospitalization for COVID-19 was 52% overall, 80% during the Delta variant period, and 38% during the Omicron variant period. Effectiveness increased when the vaccine was received after 20 weeks of pregnancy.