Browse Infectious Disease General Articles by Topic

COVID-19: Beware Remdesivir Resistance

Hogan and colleagues reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in ribonucleic acid (RNA)-dependent RNA polymerase after remdesivir treatment.

Evidence of Clinical Efficacy of Bebtelovimab in COVID-19

A retrospective study found that bebtelovimab has efficacy similar to that of nirmatrelvir/ritonavir (Paxlovid) in the treatment of high-risk outpatients with recent onset of COVID-19 who have mild to moderate symptoms.

Oseltamivir for Pediatric Inpatients with Influenza

A large study of children hospitalized with influenza clearly shows that oseltamivir given at or near the time of admission is effective in reducing the duration of hospitalization, reducing the requirement for intensive care, and reducing subsequent readmissions within the week after discharge.

Antibiotic Resistance: We Were Doing Great and then COVID Happened

After improvement, antimicrobial resistance in the United States significantly increased.

The Dental Procedure-Infective Endocarditis Link Controversy Continues

Infective endocarditis was more common with dental surgery or tooth extractions in the preceding four weeks in high-risk patients. Researchers abrogated this risk with antibiotic prophylaxis before the procedure.

Bivalent COVID-19 Vaccine (Booster Dose)

The FDA has amended the emergency use authorizations of two leading COVID-19 vaccines. Now, these new bivalent formulations can be used as a single booster dose (after primary or booster vaccination).

How Did Paralytic Polio Re-Emerge in the U.S.?

Most outbreaks globally are attributed to vaccine-derived polio, or type 2. Cases of the type 2 form of polio stem from the large-scale, global use of the oral polio vaccine, a solution that contains a live (but weakened) virus.

Frontline Providers Must Consider Dual Threats of AFM Resurgence, Polio Return

The CDC is advising frontline providers of a potential surge in cases of acute flaccid myelitis (AFM), a rare, polio-like complication of certain enteroviruses. Concurrently, there are concerns about the re-emergence of poliomyelitis.

Doxycycline Plus a Beta-Lactam for Treatment of Inpatients with Community-Acquired Pneumonia

In this retrospective study of an elderly male population hospitalized with community-acquired pneumonia, the combination of doxycycline with a beta-lactam was at least as effective as a respiratory fluoroquinolone or a combination of a beta-lactam with azithromycin.

Remaining Questions in Syphilis Treatment

Eight leading experts on sexually transmitted diseases convened to discuss key questions in the management of syphilis in adults with and without HIV infection based on a systematic review of the literature. More than 3,000 articles were screened, and the discussion focused on 95 relevant publications and three main topics.