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A New Drug for Heart Failure with Preserved Ejection Fraction?

The addition of the nonsteroidal mineralocorticoid receptor antagonist finerenone to standard therapy reduced the incidence of recurrent heart failure and death compared to placebo in patients with heart failure and mildly reduced or preserved left ventricular ejection fraction and was generally well tolerated.

Early Bird or Night Owl: Who’s Mentally Sharper?

A large cross-sectional analysis of adults aged 53-86 years found that people with normal sleep durations while being “night owls” often scored higher on cognitive tests than “early bird” types.

Eat Your Fruits and Veggies to Decrease HPV Infection

The authors of a study theorized that the increase in vitamin C and other immunological benefits of a regular diet including dark green vegetables and beans and fruits may reduce inflammation and enhance the immune system response, facilitating clearance of genital human papillomavirus.

Immediate vs. Delayed Postpartum Long-Acting Reversible Contraception

Administering long-acting reversible contraceptives before hospital discharge reduced pregnancy risk and increased usage at six months, making it an effective option for postpartum contraception.

Are Deep Contraceptive Implant Removals Predictable?

In this retrospective cohort study of 747 patients undergoing contraceptive implant removal, lower body mass index at insertion, weight gain during use, and longer duration of use were risk factors for deep contraceptive implant removal procedures.

HPV Vaccination Disparities Among Adult Women in the United States

A longitudinal, cross-sectional cohort study of 113,344 participants demonstrated that lack of health insurance, lack of stable employment, and lower income were significantly associated with decreased human papillomavirus vaccination uptake in women aged 18-47 years residing in the United States.

Lebrikizumab-lbkz Injection (Ebglyss)

The U.S. Food and Drug Administration has approved a humanized monoclonal antibody that targets interleukin-13 for the treatment of moderate-to-severe atopic dermatitis.

Metformin Reduces SARS-CoV-2 Viral Load in Outpatients with COVID-19

A randomized, placebo-controlled clinical trial of outpatients with COVID-19 found that metformin reduced SARS-CoV-2 viral load 3.6-fold compared to placebo, while ivermectin and fluvoxamine showed no benefit.

Blood Biomarker for the Diagnosis of Alzheimer’s Disease

In this population-based study of patients in Sweden with cognitive complaints, mild cognitive impairment, and dementia, the use of blood biomarkers, specifically, phosphorylated tau 217 and amyloid-beta 42/40 ratios, improved the diagnostic accuracy for pathological Alzheimer’s disease in primary care patients as well as patients seen by dementia specialists.

Treatment Direction After Unsuccessful Attempts at Smoking Cessation

This randomized trial found that, for patients unable to stop smoking after six weeks of treatment, increasing the dose of either varenicline or combination nicotine replacement therapy (CNRT) or switching from CNRT to varenicline, leads to an increased likelihood of success.