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A New Drug for Heart Failure with Preserved Ejection Fraction?

The addition of the nonsteroidal mineralocorticoid receptor antagonist finerenone to standard therapy reduced the incidence of recurrent heart failure and death compared to placebo in patients with heart failure and mildly reduced or preserved left ventricular ejection fraction and was generally well tolerated.

Beyond the Symptoms: A Primary Care Approach to Depression Management

In the vast mosaic of primary care, depression often remains in the shadows, embedded in patient care but easily overlooked. Left unrecognized, the prognosis worsens and complicates the management of other chronic conditions. However, with timely identification and effective treatment, the course of depression can be altered significantly. A comprehensive understanding of this condition, coupled with effective treatment strategies, empowers the primary care physician to mitigate the potentially debilitating effects of this condition.

Look for the Pattern

How would you interpret the two-lead rhythm strip shown in the figure? Hint: Is there a pattern?

Nalmefene Injection (Zurnal) and Intranasal Nalmefene HCl (Opvee)

The U.S. Food and Drug Administration has approved the first nalmefene autoinjector for the emergency treatment of known or suspected opioid overdose. Nalmefene is an opioid antagonist and an analog of naltrexone. It was granted a priority review and accelerated approval with a breakthrough therapy designation. It is distributed by Purdue Pharma L.P. as Zurnal.

A Review of HIV Pre-Exposure Prophylaxis

Human immunodeficiency virus (HIV) pre-exposure prophylaxis is a tool for preventing HIV, especially among high-risk populations. Three medication options are available. Regular screening for HIV and sexually transmitted infections is required, and adherence is crucial for effectiveness. PrEP is underused but increasingly covered by insurance, offering an important preventive option in sexual healthcare.

Clarifying the Risk of Aortic Aneurysm Development

A large, cross-sectional study of adults by aortic computed tomography angiography has shown that aortic aneurysms (AAs) are more frequent in men than women. While increasing age and body surface area were common risk factors for AA, hypertension was associated with thoracic AA, and hypercholesterolemia and smoking were risk factors for abdominal AA.

Poor Diabetes Control Associated with Poorer Coronary Stent Outcomes

In this large, observational study of diabetic patients with coronary stents, poorer glycemic control as measured by hemoglobin A1c was associated with stepwise hazard for stent failure over a period of more than six years, primarily driven by in-stent restenosis.

Does Semaglutide Protect Against Adverse Effects from COVID-19?

Semaglutide recipients who developed COVID-19 had significant protection against the occurrence of adverse outcomes, including death.

Placenta Accreta Spectrum Among Patients Seeking Abortion

Placenta accreta spectrum (PAS) in patients seeking abortions poses significant risks, especially for those with prior cesarean deliveries. PAS, often related to prior cesarean deliveries, increases abortion-related complications. Ultrasound is key for detection, but access to skilled care may be limited because of state-based abortion restrictions, leading to worse outcomes for affected patients.

Antibiotic Choice for Preventing SSIs in Gynecologic Surgery

In a retrospective review of 3,087 patients undergoing hysterectomy or laparotomy for gynecologic surgery at a single institution who received cefazolin alone or a combination cefazolin and metronidazole for surgical prophylaxis, the combination resulted in a significantly lower surgical site infection rate (4.5% vs. 2.3%; P = 0.0115).