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Regret in Younger Patients After Minimally Invasive Hysterectomy

A matched retrospective cohort study including 77 participants younger than 30 years of age and 164 participants aged 31-49 years demonstrated that a younger participant cohort had significantly higher rates of surgical and loss-of-fertility regret compared with an older participant cohort (32.5% vs. 9.1%, P < 0.001 and 39.0% vs. 13.4%, P < 0.001, respectively).

Preterm Birth and the RSV Vaccine During Pregnancy

The follow-up MATISSE study explored the safety of the respiratory syncytial virus prefusion F (RSVpreF) vaccine in pregnant women and demonstrated no significant increase in preterm birth rates compared to the placebo, although it highlighted geographical and socioeconomic disparities in outcomes.

Wine Consumption and Cardiovascular Health

A case-cohort subgroup of the PREDIMED study of older Mediterranean subjects at high cardiovascular disease risk, which used urinary tartaric acid to quantitate wine consumption, has shown over an almost five-year follow-up that light to moderate wine consumption was associated with a significant reduction in cardiovascular disease events.

Combustible vs. Electronic Cigarettes Post-PCI

A large, nationwide South Korean study of smokers undergoing percutaneous coronary intervention (PCI) has shown that electronic cigarette use and smoking cessation resulted in similarly lower subsequent major adverse cardiac events compared to continued smoking.

Cardiovascular Risk with mRNA COVID Vaccines

A large, nationwide population study in Sweden of the risk of adverse cardiovascular events after messenger ribonucleic acid (mRNA) COVID-19 vaccinations has shown that, except for rare cases of myopericarditis, severe cardiovascular events, such as myocardial infarction, heart failure, and stroke, are reduced, probably because of the prevention of COVID infection.

Indications for Bioprosthetic vs. Mechanical Aortic Valve Replacement

A large U.S. database study comparing mechanical vs. bioprostheses for surgical aortic valve replacement in patients 40 to 75 years of age has shown that all-cause mortality is reduced with a mechanical valve in those age 60 years or younger.

POPular PAUSE TAVI Trial Supports Interrupting Oral Anticoagulation Before TAVR in Patients with Afib

In this investigator-initiated, open-label trial, continuing oral anticoagulation leading up to a transcatheter aortic valve replacement procedure led to more bleeding and no reduction in thromboembolic events compared with interrupting anticoagulation.

Tirzepatide Injection (Zepbound) for Obstructive Sleep Apnea

The U.S. Food and Drug Administration has approved tirzepatide for the treatment of moderate-to-severe sleep apnea in adults with obesity.

Clostridioides difficile: Reduced Susceptibility to Vancomycin?

Many sites have been reluctant to prescribe fidaxomicin as the first-line agent, despite fairly robust evidence indicating its efficacy relative to vancomycin in preventing recurrences. We still cannot predict who will do well with vancomycin and which patients are likely to relapse or to do more poorly. The gradual emergence of Clostridioides difficile with reduced vancomycin susceptibility may contribute to adverse outcomes when using this agent.

Antiplatelet Therapy for Coronary Stent Patients Undergoing Noncardiac Surgery

A larger randomized controlled trial of aspirin monotherapy vs. no antiplatelet therapy in patients more than one year post-drug-eluting coronary stent placement failed to show a difference in ischemic outcomes or major bleeding, but minor bleeding was more common in the aspirin group.