Clinical Publication
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Novel Drug-Coated Balloon Compares Favorably to DES in De Novo Disease and ISR
In two related largest-to-date clinical trials, a sirolimus-eluting balloon was noninferior to current-generation drug-eluting stents (DES) in both de novo lesions and in-stent restenosis (ISR).
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The History Matters!
How would you interpret today’s 12-lead electrocardiogram and long lead V1 rhythm strip if the history was that of an older adult with known coronary disease? Would your interpretation change if, instead, the patient was a younger adult with a known history of severe congenital heart disease, having been operated on a number of times as a child?
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Paltusotine (Palsonify) Tablets
The U.S. Food and Drug Administration has approved paltusotine, the second oral (after octreotide), but first once-daily formulation for the treatment of acromegaly in adults.
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Recombinant Herpes Zoster Vaccine in a Medicare Population
Receipt of adjuvanted recombinant herpes zoster vaccine was effective in individuals older than 64 years of age and maintained its efficacy in immunocompromised individuals. Added benefit accrued from receipt of the second vaccine dose, even if its administration was delayed.
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COVID-19 Rebound: To Retreat or to Re-Treat
Re-treatment of non-immunocompromised patients with mild-moderate COVID-19 rebound with nirmatrelvir/ritonavir provided no significant benefit.
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Potential Benefit of Glyburide in Moderate-Volume Acute Ischemic Stroke
An exploratory analysis of the CHARM trial suggests intravenous glyburide may improve outcomes in large hemispheric stroke patients with infarct volumes < 125 mL, particularly alongside thrombectomy, reducing edema, mortality, and the need for decompressive surgery, and highlighting a potential neuroprotective role.
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Acupuncture to Treat Low Back Pain in Older Adults
A multisite, three-arm, parallel-group randomized clinical trial of older adults in the United States with chronic low back pain found improvement in both pain and disability with the addition of acupuncture treatment compared to usual medical care alone.
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Outpatient Management of Patients with VTE Diagnosed in the ED
Many low-risk patients with venous thromboembolism diagnosed in the emergency department can safely be treated outside the hospital. Studies show that outpatient management achieves similar outcomes to inpatient care in terms of recurrence and bleeding, while improving convenience and reducing healthcare costs.
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Elamipretide Injection (Forzinity)
The U.S. Food and Drug Administration has granted accelerated approval to elamipretide, the first treatment for Barth syndrome — a life-threatening disease of the mitochondria. Elamipretide is a mitochondrial cardiolipin binder that improves mitochondrial structure and function.
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Psychiatric Medications and Long QT Syndrome: A Safe Combination?
A retrospective study of patients with electrocardiogram long QT interval syndrome and psychiatric disease suggests that with proper pharmacologic treatment and counseling, the patients can be treated safely with psychiatric drugs known to increase the QT interval.