Clinical Publication
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Increased Treatment Opportunities for Trigeminal Autonomic Cephalalgias
Trigeminal autonomic cephalalgias (TACs) include cluster headache, paroxysmal hemicrania, hemicrania continua, short-lasting unilateral neuralgiform headache with conjunctival injection and tearing, and short-lasting unilateral neuralgiform headache with cranial autonomic symptoms. They are female-predominant primary headache disorders that coexist with migraines and mood disorders. Indomethacin is underused in those TACs that are specifically indomethacin responsive. Noninvasive vagus nerve stimulation for TACs is well-tolerated and more effective for prevention than as an acute treatment.
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Pertussis: Concerning News from Mexico, Brazil, and China
Related to under-immunization of pregnant women and children, pertussis is spreading in several countries within the Americas. Macrolide resistance of Bordetella pertussis is now common in China.
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Preventing SARS-CoV-2 Infection with an Allergy Nasal Spray
Use of the antihistamine azelastine nasal spray was effective in preventing SARS-CoV-2 infection in young, healthy, vaccinated outpatients.
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Patients Aged 6 Months and Older with Egg Allergy Should Receive Flu Vaccine
The Advisory Committee on Immunization Practices (ACIP) provided updated guidance for the 2025-2026 influenza season. After reviewing data on egg-based influenza vaccines, ACIP reinforced that individuals with egg allergies are not at increased risk of severe allergic reactions and outlined precaution and contraindication considerations in vaccine administration for this population.
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Brensocatib Tablets (Brinsupri)
The U.S. Food and Drug Administration has approved brensocatib, the first dipeptidyl peptidase-1 inhibitor and the first drug approved for non-cystic fibrosis bronchiectasis.
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The Health and Economic Burden of Long COVID in the United States
Researchers using a computational simulation model found that the current health and economic burden of long COVID already exceeds the cost of several chronic diseases and will continue to grow as COVID-19 cases increase.
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Beta-Blocker Interruption Post-MI
An analysis of the secondary outcomes in the French multicentered study of beta-blocker withdrawal in patients with uncomplicated myocardial infarction after one year led to increases in heart rate and blood pressure with potentially deleterious outcomes, especially in patients with a history of hypertension.
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Statins for Abdominal Aortic Aneurysms
An analysis of two large, abdominal aortic aneurysm (AAA) screening populations from Denmark has shown that high-dose statin therapy reduces the rate of AAA growth, the need for repair, and adverse outcomes, such as rupture and death.
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Community-Acquired Pneumonia Guidelines: Updates and Disputes
An update of elements of community-acquired pneumonia guidelines has been published. Of note is that these were not endorsed by the Infectious Diseases Society of America because of disagreement over recommendations for empiric antibiotic administration to some patient subsets with positive tests for respiratory viral infection.
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The Walk ’n Watch Trial: Stroke Recovery Through High-Intensity Walking
An intensive real-life walking protocol, started as soon as possible after acute stroke, resulted in improved overall walking endurance, mobility, balance, and quality of life