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Examination and Imaging Correlates of Visual Symptoms in Mild TBI

This study highlights measurable visual and structural changes in patients with mild traumatic brain injury (mTBI). Findings include convergence insufficiency, reduced contrast sensitivity, and occipital cortex changes, despite normal standard imaging and visual field tests. Machine learning discerned mTBI from controls with 72% accuracy, suggesting advanced diagnostics can uncover subtle abnormalities.

Monotruncular (Monomelic) CIDP

In this study, the authors describe the clinical, electrophysiological, and radiological features of patients with multifocal chronic inflammatory demyelinating polyneuropathy (CIDP) that presented with monotruncular (monomelic) onset.

From Exhaustion to Empowerment: Combating Physician Burnout in Healthcare

Medicine always has been demanding, both emotionally and intellectually. Yet, primary care providers have found deep purpose in their work. However, the modern practice of medicine brings new challenges, such as administrative burdens, financial strain, and large patient loads, contributing to widespread burnout. This paper examines burnout in the primary care provider and its related consequences and offers practical strategies for supporting provider well-being.

Cardioprotective Therapy Initiation in Chemotherapy Patients

An international study of patients undergoing cancer chemotherapy or left chest radiation therapy showed that those who showed isolated reductions in echocardiography left ventricular global longitudinal strain but not ejection fraction during follow-up who were randomized to neurohormonal therapy vs. usual care showed better preservation of 12-month cardiac magnetic resonance-determined ejection fraction.

Prognostic Value of Stress Echocardiography

A UK National Health Service database study of stress echocardiography has shown the degree of ischemia accurately predicts the risk of future cardiovascular events over five years. The same study also showed that a negative test in patients without a history of cardiac disease identifies patients with no more than the expected background risk of an event for patients in this demographic for five years.

EARLY TAVR Study Reports a Win for TAVR in Asymptomatic Severe AS

In this multicenter, randomized trial comparing transcatheter aortic valve replacement (TAVR) with active surveillance in patients with asymptomatic severe aortic stenosis (AS), early TAVR showed an advantage regarding the composite endpoint of death, stroke, or unplanned hospitalization for cardiovascular causes. This result was driven primarily from the progression to severe symptomatic AS among the surveillance group, with no significant difference in mortality.

Cardiac and Paracardiac Structure in the SUMMIT Trial

A cardiac magnetic resonance imaging study in a subgroup of the patients in the SUMMIT trial of tirzepatide in patients with heart failure with preserved ejection fraction has demonstrated that patients treated with tirzepatide had reduced left ventricular mass and paracardiac adipose tissue compared to placebo-treated patients, which may partially explain the reduction in heart failure events observed in the main SUMMIT trial.

A New Treatment for Heart Failure with Preserved Ejection Fraction

A recent randomized, placebo-controlled trial of the long-acting glucagon-like peptide-1 receptor agonist tirzepatide in patients with heart failure with preserved left ventricular ejection fraction who have obesity, diabetes, and one other weight-related comorbidity has shown that tirzepatide not only reduces the symptoms of heart failure, but reduces the incidence of worsening heart failure events.

Endometrial Cancer: An Update to Classification Using Molecular Features

The classification of endometrial cancer is evolving, transitioning from histological subtypes to molecular profiling. Four key molecular subtypes (POLE ultramutated, MSI unstable, p53 mutant, and NSMP) guide prognosis and treatment. The integration of molecular features into staging highlights their clinical relevance for improving diagnostic accuracy and therapeutic strategies.

Adverse Outcome Predictors in Pregnancies Complicated by SLE

A prior history of lupus nephritis, active systemic lupus erythematosus (SLE) at conception, secondary antiphospholipid syndrome, and chronic hypertension are critical predictors of adverse pregnancy outcomes in women with SLE.