Browse Clinical Publication Articles by Topic

Transfusion Therapy in Aneurysmal Subarachnoid Hemorrhage

The SAHARA trial evaluated liberal vs. restrictive red blood cell transfusion strategies in aneurysmal subarachnoid hemorrhage (SAH) patients with anemia. No significant difference in neurological outcomes at 12 months was found. Findings add to existing uncertainty regarding transfusion thresholds in SAH, highlighting the need for further research.

Diagnosis and Outcome of Reversible Cerebral Vasoconstriction Syndrome

Reversible cerebral vasoconstriction syndrome (RCVS) is a rare disorder characterized by thunderclap headaches and cerebral vasoconstriction resolving within 90 days. A retrospective study of 80 patients found favorable outcomes, with most treated using calcium channel blockers. However, challenges in RCVS diagnosis and classification may affect reported outcomes.

From Glucocentricity to a Multi-Risk Strategy: An Updated Approach to Managing Chronic Kidney Disease

This article discusses an important microvascular complication of diabetes mellitus, chronic kidney disease (CKD), which affects more than one-third of patients with diabetes. There is substantial evidence that early diagnosis and management can delay or prevent the progression of CKD, making its prevention, diagnosis, and treatment a priority for the primary care clinician.

DeWinter T Waves?

The electrocardiogram (ECG) in the figure was obtained from a woman with dyspnea and marked hypertension, but who had no chest pain. How would you interpret this ECG? Should you activate the cath lab?

Nemolizumab-Ilto (Nemluvio)

The U.S. Food and Drug Administration has approved nemolizumab, the first monoclonal antibody specifically targeting the interleukin-31 pathway linked to pruritus and skin inflammation associated with atopic dermatitis.

ABCD² Score as a Predictor of Three-Year Stroke Risk

This retrospective cohort study using the National Patient Registry in Denmark analyzed a three-year follow-up period following a transient ischemic attack, looking at the rate of recurrent stroke and mortality. The patients were divided into low risk (ABCD² score 0-3) and high risk (ABCD² score ≥ 4). The stroke rate was 6% in the high-risk group and 4% in the low-risk group.

Examining the Effectiveness of Using AI Tools in Practice

A controlled trial comparing physician diagnostic performance with and without artificial intelligence (AI) found no significant difference in accuracy, quality, or other metrics, although AI alone outperformed both groups.

Prognostic Value of Stress Echocardiography

A UK National Health Service database study of stress echocardiography has shown the degree of ischemia accurately predicts the risk of future cardiovascular events over five years. The same study also showed that a negative test in patients without a history of cardiac disease identifies patients with no more than the expected background risk of an event for patients in this demographic for five years.

Cesarean Scar Ectopic Pregnancy

Cesarean scar ectopic pregnancy is a complication in which an embryonic pregnancy implants in the fibrous scar of a previous cesarean incision. This abnormally located pregnancy places the patient at increased risk for uterine dehiscence, hemorrhage, and abnormal placentation as the pregnancy progresses.

How Common Are Hormonal Side Effects with the 52-mg Levonorgestrel IUD?

In this secondary analysis of the ACCESS IUS trial, participants who used combined hormonal contraceptives compared to nonhormonal contraceptives prior to enrolling were more likely to complain of acne in the first six months (13% vs. 8.5%, P = 0.006) and 12 months (15.7% vs. 10.6%, P = 0.005) of levonorgestrel intrauterine device use. Overall, the rate of discontinuation in the first six months because of adverse events was 5.5%, with no difference between the two groups.