Vaccines
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Comprehensive Data Analysis Validates the Effectiveness and Safety of COVID-19, RSV, and Influenza Vaccination
Respiratory syncytial virus, influenza, and COVID-19 vaccines are safe and effective.
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COVID-19 Vaccine Receipt Was Associated with Better Clinical Outcomes in U.S. Veterans
An observational study from the Department of Veterans Affairs found that individuals who received the 2024-2025 COVID-19 vaccine and the influenza vaccine on the same day had fewer emergency department visits, COVID-19-associated hospitalizations, and deaths related to COVID-19 compared to a group that only received the influenza vaccine.
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An Oral Vaccine Against Salmonella Paratyphi A Shows Promise
In a Phase IIb controlled human infection model study, the oral live attenuated vaccine CVD 1902 demonstrated 73% efficacy against Salmonella Paratyphi A infection, with a favorable safety profile and robust immunogenicity, supporting advancement toward field trials in endemic populations.
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Recombinant Herpes Zoster Vaccine in a Medicare Population
Receipt of adjuvanted recombinant herpes zoster vaccine was effective in individuals older than 64 years of age and maintained its efficacy in immunocompromised individuals. Added benefit accrued from receipt of the second vaccine dose, even if its administration was delayed.
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Current Recommendations for Childhood Respiratory Vaccines
Amidst prevalent vaccine hesitancy, changing governmental advisory groups, and altered recommendations, COVID immunization still is recommended for all children aged 6 through 23 months and for older children with medical risk factors.
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Pertussis: Concerning News from Mexico, Brazil, and China
Related to under-immunization of pregnant women and children, pertussis is spreading in several countries within the Americas. Macrolide resistance of Bordetella pertussis is now common in China.
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Patients Aged 6 Months and Older with Egg Allergy Should Receive Flu Vaccine
The Advisory Committee on Immunization Practices (ACIP) provided updated guidance for the 2025-2026 influenza season. After reviewing data on egg-based influenza vaccines, ACIP reinforced that individuals with egg allergies are not at increased risk of severe allergic reactions and outlined precaution and contraindication considerations in vaccine administration for this population.
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Routine Boosting Against Tetanus and Diphtheria in Adults: A Time to Reconsider
Slifka and colleagues make a strong argument against the routine booster vaccination of adults against tetanus and diphtheria as recommended by the Centers for Disease Control and Prevention.
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Aluminum-Adsorbed Vaccines and Chronic Diseases in Children
A large Danish cohort study of 1.2 million children found no association between cumulative aluminum exposure from childhood vaccines and increased risk for autoimmune, atopic/allergic, or neurodevelopmental disorders, adding to nearly a century of safety data for aluminum adjuvants, although the study’s findings have been the subject of public debate about interpretation of secondary analyses.
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Routine Boosting Against Tetanus and Diphtheria in Adults: A Time to Reconsider
Slifka and colleagues make a strong argument against the routine booster vaccination of adults against tetanus and diphtheria as recommended by the Centers for Disease Control and Prevention.