Neurology
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Genetic Evaluation of Hereditary Spastic Paraplegia
Hereditary spastic paraplegia (HSP) refers to a group of rare, clinically heterogenous degenerative neurogenetic disorders resulting in spasticity, gait impairment, and falls as the result of a length-dependent upper motor neuron degeneration. Next-generation sequencing with multigene panels or exome analysis can confirm molecular diagnosis of approximately 30% of HSP patients. Multigene panels can identify the common causative variants, variants on rarely involved genes, and structural rearrangements.
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Mavacamten Capsules (Camzyos)
Mavacamten can be prescribed to adults with symptomatic New York Heart Association class II-III obstructive hypertrophic cardiomyopathy to improve functional capacity and symptoms.
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HPV Vaccination in Adolescence Prevents Cancer More than 10 Years Later
In a study of human papillomavirus (HPV) vaccination, researchers evaluated cancer protection over up to 11 years of follow-up. During this time, the authors noted 100% vaccine efficacy at preventing HPV-associated cancers.
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Regarding Exercise Capacity Past Age 75 Years, What Is Normal?
A group of researchers delivered results that could help inform clinicians about the expected exercise test performance of older patients.
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Recommendations Regarding Physical Activity to Delay Death
Using objective measurements of exercise intensity, researchers approximated 110,000 U.S. deaths/year could be prevented by a 10-minute daily increase in moderate-to-vigorous physical activity in adults age 40-85 years.
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Beware the Cardiovascular Risks Associated with Thyroid Hormone Replacement Therapy
Thyroid levels outside the euthyroid range have been associated with higher cardiovascular risk in patients taking thyroid hormone to treat hypothyroidism. In this study, a higher cardiovascular mortality rate was associated with exogenous hyperthyroidism and exogenous hypothyroidism.
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Did You See Both ECG Findings?
The ECG in the figure was obtained from an older man with new chest pain. There are two principal ECG findings on this tracing. Do you see both?
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Oteseconazole Capsules (Vivjoa)
The FDA has approved the first drug to reduce recurrent vulvovaginal candidiasis.
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Neurodegeneration Biomarkers in Patients with Subjective Cognitive Complaints
In individuals with subjective cognitive decline, multiple biomarkers of neurodegeneration were found to add predictive values beyond amyloid and tau biomarkers.
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Does Amantadine Treatment Reduce Levodopa-Induced Dyskinesias?
Early treatment with amantadine may delay levodopa-induced dyskinesia onset more than treatment with other symptomatic agents.